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1WDL	fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form II (native4) Descriptor: 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ... Authors: Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K. Deposit date: 2004-05-17 Release date: 2004-07-27 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex Embo J., 23, 2004
1M3K	biosynthetic thiolase, inactive C89A mutant Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION Authors: Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. Deposit date: 2002-06-28 Release date: 2002-11-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
1OU6	Biosynthetic thiolase from Zoogloea ramigera in complex with acetyl-O-pantetheine-11-pivalate Descriptor: Acetyl-CoA acetyltransferase, PANTOTHENYL-AMINOETHANOL-ACETATE PIVALIC ACID, SULFATE ION Authors: Kursula, P, Schmitz, W, Wierenga, R.K. Deposit date: 2003-03-24 Release date: 2004-06-01 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.07 Å) Cite: The surprising binding mode of a coenzyme A analogue, O-pantetheine-11-pivalate, in the catalytic cavity of bacterial biosynthetic thiolase To be Published
1NL7	Z. ramigera biosynthetic thiolase, acetylated enzyme complexed with CoA at pH 9.5 Descriptor: Acetyl-CoA acetyltransferase, COENZYME A, SULFATE ION Authors: Kursula, P, Wierenga, R.K. Deposit date: 2003-01-06 Release date: 2004-04-06 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.903 Å) Cite: Crystal structures of Z. ramigera biosynthetic thiolase To be Published
1M1O	Crystal structure of biosynthetic thiolase, C89A mutant, complexed with acetoacetyl-CoA Descriptor: ACETOACETYL-COENZYME A, Acetyl-CoA acetyltransferase, SULFATE ION Authors: Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. Deposit date: 2002-06-20 Release date: 2002-11-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
1M4T	Biosynthetic thiolase, Cys89 butyrylated Descriptor: Acetyl-CoA acetyltransferase, GLYCEROL, SULFATE ION Authors: Kursula, P, Ojala, J, Lambeir, A.-M, Wierenga, R.K. Deposit date: 2002-07-03 Release date: 2002-11-29 Last modified: 2018-03-07 Method: X-RAY DIFFRACTION (1.77 Å) Cite: The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes Biochemistry, 41, 2002
1PXT	THE 2.8 ANGSTROMS STRUCTURE OF PEROXISOMAL 3-KETOACYL-COA THIOLASE OF SACCHAROMYCES CEREVISIAE: A FIVE LAYERED A-B-A-B-A STRUCTURE, CONSTRUCTED FROM TWO CORE DOMAINS OF IDENTICAL TOPOLOGY Descriptor: PEROXISOMAL 3-KETOACYL-COA THIOLASE Authors: Mathieu, M, Wierenga, R.K. Deposit date: 1994-07-04 Release date: 1994-08-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The 2.8 A crystal structure of peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: a five-layered alpha beta alpha beta alpha structure constructed from two core domains of identical topology. Structure, 2, 1994
2IBU	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: Acetyl-CoA acetyltransferase, CHLORIDE ION, COENZYME A, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-12 Release date: 2007-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
2IBW	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-12 Release date: 2007-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
2IB8	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-11 Release date: 2007-04-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
2IIK	Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1) Descriptor: 3-ketoacyl-CoA thiolase, peroxisomal Authors: Papagrigoriou, E, Johansson, C, Smee, C, Kavanagh, K, Pike, A.C.W, Sundstrom, M, Weigelt, J, Edwards, A, Arrowsmith, C.H, Gileadi, O, Gorrec, F, Umeano, C, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2006-09-28 Release date: 2006-10-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1) TO BE PUBLISHED
2IB7	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-11 Release date: 2007-04-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
2IB9	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-11 Release date: 2007-04-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
2IBY	Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Haapalainen, A.M, Wierenga, R.K. Deposit date: 2006-09-12 Release date: 2007-04-03 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46, 2007
4C2K	Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... Authors: Kiema, T.-R, Harijan, R.K, Wierenga, R.K. Deposit date: 2013-08-19 Release date: 2014-09-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities Acta Crystallogr.,Sect.D, 70, 2014
4B3H	Crystal structure of Mycobacterium tuberculosis fatty acid beta- oxidation complex Descriptor: FATTY ACID BETA-OXIDATION COMPLEX ALPHA-CHAIN FADB, FATTY ACID BETA-OXIDATION COMPLEX BETA-CHAIN FADA, GLYCEROL, ... Authors: Venkatesan, R, Wierenga, R. Deposit date: 2012-07-24 Release date: 2013-03-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of Mycobacterial Beta-Oxidation Trifunctional Enzyme Reveals its Altered Assembly and Putative Substrate Channeling Pathway. Acs Chem.Biol., 8, 2013
4C2J	Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA Descriptor: 1,2-ETHANEDIOL, 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, ... Authors: Kiema, T.-R, Harijan, R.K, Wierenga, R.K. Deposit date: 2013-08-19 Release date: 2014-09-03 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2 Å) Cite: The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities Acta Crystallogr.,Sect.D, 70, 2014
4B3I	Crystal structure of Mycobacterium tuberculosis fatty acid beta- oxidation complex with CoenzymeA bound at the hydratase active sites Descriptor: ADENOSINE-5'-DIPHOSPHATE, COENZYME A, FATTY ACID BETA-OXIDATION COMPLEX ALPHA-CHAIN FADB, ... Authors: Venkatesan, R, Wierenga, R.K. Deposit date: 2012-07-24 Release date: 2013-03-27 Last modified: 2013-05-29 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Structure of Mycobacterial Beta-Oxidation Trifunctional Enzyme Reveals its Altered Assembly and Putative Substrate Channeling Pathway. Acs Chem.Biol., 8, 2013
7LDV	Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E/delH221/S227K mutant Descriptor: AMMONIUM ION, Acetyl-CoA acetyltransferase, CHLORIDE ION, ... Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-14 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LDW	Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E/delH221/S227K/G248T mutant Descriptor: AMMONIUM ION, Acetyl-CoA acetyltransferase, COENZYME A, ... Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-14 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LDU	Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E/delH221 mutant Descriptor: Acetyl-CoA acetyltransferase, CHLORIDE ION, COENZYME A, ... Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-14 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LCA	Zoogloea ramigera biosynthetic thiolase Y218E/delH221 mutant Descriptor: Acetyl-CoA acetyltransferase, CHLORIDE ION, COENZYME A, ... Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-10 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LDC	Zoogloea ramigera biosynthetic thiolase Q183Y/Y218E mutant Descriptor: Acetyl-CoA acetyltransferase, COENZYME A, SULFATE ION Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-13 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LCL	Zoogloea ramigera biosynthetic thiolase Q183Y mutant Descriptor: AMMONIUM ION, Acetyl-CoA acetyltransferase, COENZYME A, ... Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-11 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.295 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021
7LBZ	Zoogloea ramigera biosynthetic thiolase Y218E mutant Descriptor: Acetyl-CoA acetyltransferase, COENZYME A, SULFATE ION Authors: Marshall, A.C, Bruning, J.B. Deposit date: 2021-01-09 Release date: 2021-09-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Engineering potassium activation into biosynthetic thiolase. Biochem.J., 478, 2021

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