4C2J

Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA

Summary for 4C2J

• Entry DOI: 10.2210/pdb4c2j/pdb
• Related: 4C2K
• Descriptor: 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, 1,2-ETHANEDIOL, COENZYME A, ... (4 entities in total)
• Functional Keywords: transferase, fatty acid metabolism, mitochondrial beta-oxidation, thiolytic cleavage
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Mitochondrion : P42765
• Total number of polymer chains: 4
• Total formula weight: 180708.90

Authors

Kiema, T.-R.,Harijan, R.K.,Wierenga, R.K. (deposition date: 2013-08-19, release date: 2014-09-03, Last modification date: 2023-12-20)

• Primary citation: Kiema, T.-R.,Harijan, R.K.,Strozyk, M.,Fukao, T.,Alexson, S.E.H.,Wierenga, R.K.; The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities; Acta Crystallogr.,Sect.D, 70:3212-, 2014; PubMed: 25478839; DOI: 10.1107/S1399004714023827

Experimental method

X-RAY DIFFRACTION (2 Å)