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6O9S	Crystal structure of Staphylococcus aureus MecR1 antibiotic-sensor domain in complex with avibactam Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Methicillin resistance mecR1 protein, SULFATE ION Authors: Alexander, J.A.N, Strynadka, N.C.J. Deposit date: 2019-03-14 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus . J.Biol.Chem., 295, 2020
6O9W	Crystal structure of Staphylococcus aureus BlaR1 antibiotic-sensor domain in complex with avibactam Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Regulatory protein BlaR1 Authors: Alexander, J.A.N, Strynadka, N.C.J. Deposit date: 2019-03-15 Release date: 2020-06-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus . J.Biol.Chem., 295, 2020
6P56	Crystal structure of the transpeptidase domain of a T498A mutant of PBP2 from Neisseria gonorrhoeae Descriptor: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA Authors: Singh, A, Davies, C. Deposit date: 2019-05-29 Release date: 2019-08-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P52	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae with a bound phosphate at the active site Descriptor: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA Authors: Singh, A, Davies, C. Deposit date: 2019-05-29 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P53	Crystal structure of the transpeptidase domain of PBP2 from Neisseria gonorrhoeae in apo form Descriptor: PHOSPHATE ION, peptidoglycan D,D-transpeptidase PenA Authors: Singh, A, Davies, C. Deposit date: 2019-05-29 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P96	OXA-48 carbapanemase, apo form Descriptor: Beta-lactamase, CADMIUM ION, CALCIUM ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2019-06-10 Release date: 2019-08-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P9C	OXA-48 carbapanemase, doripenem complex Descriptor: (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2019-06-10 Release date: 2019-08-07 Last modified: 2019-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P54	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae acylated by ceftriaxone Descriptor: CEFOTAXIME, C3' cleaved, open, ... Authors: Singh, A, Davies, C. Deposit date: 2019-05-29 Release date: 2019-08-07 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6PK0	Crystal Structure of OXA-48 with Hydrolyzed Imipenem Descriptor: (2R,4S)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4-[(2-{[(Z)-iminomethyl]amino}ethyl)sulfanyl]-3,4-dihydro-2H-pyrrole-5-ca rboxylic acid, CHLORIDE ION, GLYCEROL, ... Authors: Akhtar, A, Chen, Y. Deposit date: 2019-06-28 Release date: 2020-01-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6P55	Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae acylated by cefixime Descriptor: DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, cefixime, ... Authors: Singh, A, Davies, C. Deposit date: 2019-05-29 Release date: 2019-08-07 Last modified: 2020-01-01 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Recognition of the beta-lactam carboxylate triggers acylation ofNeisseria gonorrhoeaepenicillin-binding protein 2. J.Biol.Chem., 294, 2019
6P99	OXA-48 carbapanemase, ertapenem complex Descriptor: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2019-06-10 Release date: 2019-08-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6PQI	Crystal Structure of Class D Beta-lactamase OXA-48 with Cefotaxime Descriptor: ACETATE ION, CEFOTAXIME, C3' cleaved, ... Authors: Akhtar, A, Chen, Y. Deposit date: 2019-07-09 Release date: 2020-01-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6P97	OXA-48 carbapanemase, imipenem complex Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2019-06-10 Release date: 2019-08-07 Last modified: 2019-10-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6P98	OXA-48 carbapanemase, meropenem complex Descriptor: Beta-lactamase, CADMIUM ION, CALCIUM ION, ... Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2019-06-10 Release date: 2019-08-07 Last modified: 2019-10-09 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase. Antimicrob.Agents Chemother., 63, 2019
6PSG	Crystal Structure of Class D Beta-lactamase OXA-48 with Faropenem Descriptor: (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48, ... Authors: Akhtar, A, Chen, Y. Deposit date: 2019-07-12 Release date: 2020-01-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6PTU	Crystal Structure of Class D Beta-lactamase OXA-48 with Imipenem Descriptor: CHLORIDE ION, Class D Carbapenemase OXA-48, Imipenem Authors: Akhtar, A, Chen, Y. Deposit date: 2019-07-16 Release date: 2020-01-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.004 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6PXX	Class D beta-lactamase in complex with beta-lactam antibiotic Descriptor: (2~{S},3~{R})-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: van den Akker, F, Kumar, V. Deposit date: 2019-07-28 Release date: 2019-10-09 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem. Antibiotics, 8, 2019
6PT5	Crystal Structure of Class D Beta-lactamase OXA-48 with Cefoxitin Descriptor: (2R)-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48 Authors: Akhtar, A, Chen, Y. Deposit date: 2019-07-14 Release date: 2020-01-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6PT1	Crystal Structure of Class D Beta-lactamase OXA-48 with Meropenem Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48, ... Authors: Akhtar, A, Chen, Y. Deposit date: 2019-07-14 Release date: 2020-01-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase. Acs Infect Dis., 6, 2020
6Q5F	OXA-48_P68A-CAZ. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance Descriptor: 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Beta-lactamase, CHLORIDE ION, ... Authors: Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.-K.S, Samuelsen, O. Deposit date: 2018-12-08 Release date: 2019-03-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
6Q5B	OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, CARBON DIOXIDE, ... Authors: Frohlich, C, Sorum, V, Thomassen, A.M, Johnsen, P.J, Leiros, H.K.S, Samuelsen, O. Deposit date: 2018-12-07 Release date: 2019-03-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.22 Å) Cite: OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs. Msphere, 4, 2019
6N6W	OXA-23 mutant F110A/M221A neutral pH form Descriptor: Beta-lactamase oxa23 Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2018-11-27 Release date: 2018-12-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases. Antimicrob. Agents Chemother., 63, 2019
6MPQ	1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514 Descriptor: (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, Beta-lactamase, CHLORIDE ION Authors: van den Akker, F, Kumar, V. Deposit date: 2018-10-08 Release date: 2019-02-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. MBio, 10, 2019
6N6V	OXA-23 mutant F110A/M221A low pH form meropenem complex Descriptor: Beta-lactamase, meropenem, bound form Authors: Smith, C.A, Vakulenko, S.B. Deposit date: 2018-11-27 Release date: 2018-12-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases. Antimicrob. Agents Chemother., 63, 2019
6N1N	Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386 Descriptor: Beta-lactamase, GLYCEROL, SULFATE ION Authors: Michalska, K, Tesar, C, Endres, M, Joachimiak, A, Satchell, K.J, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2018-11-09 Release date: 2018-12-19 Last modified: 2019-12-18 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Crystal structure of class D beta-lactamase from Sebaldella termitidis ATCC 33386 To Be Published

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