6P9C

OXA-48 carbapanemase, doripenem complex

Summary for 6P9C

• Entry DOI: 10.2210/pdb6p9c/pdb
• Descriptor: Beta-lactamase, (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Doripenem, ... (7 entities in total)
• Functional Keywords: antibiotic resistance, beta-lactamase, carbapenemase, dorupenem complex, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 62966.36

Authors

Smith, C.A.,Vakulenko, S.B. (deposition date: 2019-06-10, release date: 2019-08-07, Last modification date: 2019-10-09)

• Primary citation: Smith, C.A.,Stewart, N.K.,Toth, M.,Vakulenko, S.B.; Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 31358584; DOI: 10.1128/AAC.01202-19

Experimental method

X-RAY DIFFRACTION (1.9 Å)