6P99

OXA-48 carbapanemase, ertapenem complex

Summary for 6P99

• Entry DOI: 10.2210/pdb6p99/pdb
• Descriptor: Beta-lactamase, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: antibiotic resistance, beta-lactamase, carbapenemase, ertapenem complex, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 61834.80

Authors

Smith, C.A.,Vakulenko, S.B. (deposition date: 2019-06-10, release date: 2019-08-07, Last modification date: 2024-03-13)

• Primary citation: Smith, C.A.,Stewart, N.K.,Toth, M.,Vakulenko, S.B.; Structural Insights into the Mechanism of Carbapenemase Activity of the OXA-48 beta-Lactamase.; Antimicrob.Agents Chemother., 63:-, 2019; PubMed: 31358584; DOI: 10.1128/AAC.01202-19

Experimental method

X-RAY DIFFRACTION (2.25 Å)