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7L3M	PEPCK MMQX structure 40ms post-mixing with oxaloacetic acid Descriptor: CARBON DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E. Deposit date: 2020-12-18 Release date: 2021-10-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection. Iucrj, 8, 2021
2FAH	The structure of mitochondrial PEPCK, Complex with Mn and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MALONIC ACID, MANGANESE (II) ION, ... Authors: Holyoak, T, Sullivan, S.M, Nowak, T. Deposit date: 2005-12-07 Release date: 2006-06-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structural Insights into the Mechanism of PEPCK Catalysis Biochemistry, 45, 2006
4YWD	Structure of rat cytosolic pepck in complex with 2,3-Pyridine dicarboxylic acid Descriptor: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... Authors: Balan, M.D, Johnson, T.A, Mcleod, M.J, Lotosky, W.R, Holyoak, T. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015
3MOH	The structure of rat cytosolic PEPCK mutant A467G in complex with phosphoglycolate and GDP Descriptor: 1,2-ETHANEDIOL, 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2010-04-22 Release date: 2010-06-02 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
1NHX	PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ... Authors: Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J. Deposit date: 2002-12-19 Release date: 2003-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
4WOU	Crystal Structure of Mtb PEPCK in complex with GDP and metals Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Kim, H.L, Sacchettini, J.C. Deposit date: 2014-10-16 Release date: 2015-11-04 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.122 Å) Cite: Crystal Structure of Mtb PEPCK in complex with GDP and metals To Be Published
5V9H	Structure of the H477R variant of rat cytosolic PEPCK in complex with phosphoglycolate and GDP. Descriptor: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
4WIE	Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol Descriptor: GLYCEROL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase [GTP] Authors: Kim, H.L, Sacchettini, J.C. Deposit date: 2014-09-25 Release date: 2014-10-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol To Be Published
1M51	PEPCK complex with a GTP-competitive inhibitor Descriptor: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... Authors: Foley, L.H, Wang, P, Dunten, P, Wertheimer, S.J. Deposit date: 2002-07-06 Release date: 2003-09-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.25 Å) Cite: X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
4WPU	Crystal Structure of E83A mutant of Mtb PEPCK in complex with PEP and GDP Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, PHOSPHOENOLPYRUVATE, ... Authors: Kim, H.L, Sacchettini, J.C. Deposit date: 2014-10-21 Release date: 2015-11-04 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Crystal Structure of E83A mutant of Mtb PEPCK in complex with PEP and GDP To Be Published
2ZCI	Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum Descriptor: Phosphoenolpyruvate carboxykinase [GTP] Authors: Aich, S, Prasad, L, Delbaere, L.T.J. Deposit date: 2007-11-09 Release date: 2008-04-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum. Int.J.Biochem.Cell Biol., 40, 2008
2GMV	PEPCK complex with a GTP-competitive inhibitor Descriptor: MANGANESE (II) ION, N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE, PHOSPHOENOLPYRUVATE, ... Authors: Dunten, P. Deposit date: 2006-04-07 Release date: 2007-05-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg.Med.Chem.Lett., 17, 2007
5V95	Structure of the H477R variant of rat cytosolic PEPCK in complex with manganese. Descriptor: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... Authors: Holyoak, T, Cui, D.S. Deposit date: 2017-03-23 Release date: 2017-04-12 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
1KHG	PEPCK Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. Deposit date: 2001-11-29 Release date: 2002-02-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
1KHE	PEPCK complex with nonhydrolyzable GTP analog, MAD data Descriptor: MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Phosphoenolpyruvate Carboxykinase, ... Authors: Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, G.B, Swain, A, Weber, D, Wertheimer, S.J. Deposit date: 2001-11-29 Release date: 2002-02-27 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site. J.Mol.Biol., 316, 2002
4RCG	Crystal Structure Analysis of MTB PEPCK without Mn+2 Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Brynda, J, Dostal, J, Snasel, J, Fanfrlik, J, Pichova, I, Machova, I. Deposit date: 2014-09-16 Release date: 2015-04-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis. Plos One, 10, 2015
5I67	Crystal Structure Analysis of MTB PEPCK mutant C273S Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... Authors: Dostal, J, Pachl, P, Machova, I, Pichova, I, Snasel, J. Deposit date: 2016-02-16 Release date: 2016-04-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.602 Å) Cite: Crystal Structure Analysis of MTB PEPCK mutant C273S To Be Published

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