PDB: 854 件ウェブページステータス検索Chemie searchBIRD

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4N0E	Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, SULFATE ION 著者 Thaker, T.M, Preininger, A.M, Sarwar, M, Hamm, H.E, Iverson, T.M. 登録日 2013-10-01 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1. J.Biol.Chem., 289, 2014
6AU6	Crystal structure of GDP-bound human GNAS R201C mutant 分子名称: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Hu, Q, Shokat, K.M. 登録日 2017-08-30 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Disease-Causing Mutations in the G Protein G alpha s Subvert the Roles of GDP and GTP. Cell, 173, 2018
3UMS	Crystal structure of the G202A mutant of human G-alpha-i1 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Lambert, N.A, Johnston, C.A, Cappell, S.D, Kuravi, S, Kimple, A.J, Willard, F.S, Siderovski, D.P. 登録日 2011-11-14 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.343 Å) 主引用文献 Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity Proc.Natl.Acad.Sci.USA, 2012
3UMR	Crystal structure of the G202D mutant of human G-alpha-i1 分子名称: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Johnston, C.A, Afshar, K, Snyder, J.T, Tall, G.G, Gonczy, P, Siderovski, D.P, Willard, F.S. 登録日 2011-11-14 公開日 2012-10-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans To be Published
3V00	Studies of a constitutively active G-alpha subunit provide insights into the mechanism of G protein activation. 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(t) subunit alpha-1/ Guanine nucleotide-binding protein G(i) subunit alpha-1 chimeric protein 著者 Singh, G, Cerione, R.A. 登録日 2011-12-07 公開日 2012-04-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A constitutively active G-alpha subunit provide insights into the mechanism of G protein activation Biochemistry, 51, 2012
1Y3A	Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... 著者 Johnston, C.A, Willard, F.S, Jezyk, M.R, Fredericks, Z, Bodor, E.T, Jones, M.B, Blaesius, R, Harden, T.K, Sondek, J, Watts, V.J, Ramer, J.K, Siderovski, D.P. 登録日 2004-11-24 公開日 2005-07-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange Structure, 7, 2005
1ZCB	Crystal structure of G alpha 13 in complex with GDP 分子名称: G alpha i/13, GUANOSINE-5'-DIPHOSPHATE 著者 Nance, M.R, Tesmer, J.J.G. 登録日 2005-04-11 公開日 2005-11-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins. Biochemistry, 45, 2006
1ZCA	Crystal structure of G alpha 12 in complex with GDP, Mg2+ and AlF4- 分子名称: G alpha i/12, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Nance, M.R, Tesmer, J.J.G. 登録日 2005-04-11 公開日 2005-11-15 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins. Biochemistry, 45, 2006
5JS8	Structural Model of a Protein alpha subunit in complex with GDP obtained with SAXS and NMR residual couplings 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1 著者 Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F. 登録日 2016-05-07 公開日 2016-06-29 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding. Proc.Natl.Acad.Sci.USA, 113, 2016
5KDL	Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2016-06-08 公開日 2016-08-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.665 Å) 主引用文献 A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor. J.Biol.Chem., 291, 2016
5JS7	Structural model of a apo G-protein alpha subunit determined with NMR residual dipolar couplings and SAXS 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1 著者 Goricanec, D, Stehle, R, Grigoriu, S, Wagner, G, Hagn, F. 登録日 2016-05-07 公開日 2016-06-29 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Conformational dynamics of a G-protein alpha subunit is tightly regulated by nucleotide binding. Proc.Natl.Acad.Sci.USA, 113, 2016
3QE0	A Galpha-i1 P-loop mutation prevents transition to the activated state 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, ... 著者 Bosch, D.E, Willard, F.S, Kimple, A.J, Miley, M.J, Siderovski, D.P. 登録日 2011-01-19 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis Plos Pathog., 8, 2012
2G83	Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... 著者 Johnston, C.A, Ramer, J.K, Blaesius, R, Kuhlman, B, Arshavsky, V.Y, Siderovski, D.P. 登録日 2006-03-01 公開日 2006-10-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer. Biochemistry, 45, 2006
3D7M	Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... 著者 Funk, M.A, Preininger, A.M, Oldham, W.M, Meier, S.M, Hamm, H.E, Iverson, T.M. 登録日 2008-05-21 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry, 48, 2009
3FFA	Crystal Structure of a fast activating G protein mutant 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... 著者 Chauhan, R, Kapoor, N. 登録日 2008-12-02 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins. J.Mol.Biol., 393, 2009
3FFB	Gi-alpha-1 mutant in GDP bound form 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... 著者 Chauhan, R, Kapoor, N. 登録日 2008-12-02 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural evidence for a sequential release mechanism for activation of heterotrimeric g proteins. J.Mol.Biol., 393, 2009
4N0D	Crystal structure of the K345L variant of the Gi alpha1 subunit bound to GTPgammaS 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, ... 著者 Thaker, T.M, Preininger, A.M, Sarwar, M, Hamm, H.E, Iverson, T.M. 登録日 2013-10-01 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A Transient Interaction between the Phosphate Binding Loop and Switch I Contributes to the Allosteric Network between Receptor and Nucleotide in G alpha i1. J.Biol.Chem., 289, 2014
4PAN	A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2014-04-09 公開日 2014-07-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
4PAQ	A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2014-04-09 公開日 2014-07-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
4PAO	A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2014-04-09 公開日 2014-07-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.003 Å) 主引用文献 A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
4PAM	A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Kaya, A.I, Lokits, A.D, Gilbert, J, Iverson, T.M, Meiler, J, Hamm, H.E. 登録日 2014-04-09 公開日 2014-07-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.101 Å) 主引用文献 A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit. J.Biol.Chem., 289, 2014
1TAG	STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSDUCIN-ALPHA 著者 Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. 登録日 1994-11-23 公開日 1995-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature, 369, 1994
4FID	Crystal structure of a heterotrimeric G-Protein subunit from entamoeba histolytica, EHG-ALPHA-1 分子名称: G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE 著者 Bosch, D.E, Kimple, A.J, Muller, R.E, Gigure, P.M, Willard, F.S, Machius, M, Temple, B.R, Siderovski, D.P. 登録日 2012-06-08 公開日 2012-11-28 最終更新日 2013-06-26 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica. Plos Pathog., 8, 2012
1SVS	Structure of the K180P mutant of Gi alpha subunit bound to GppNHp. 分子名称: Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ... 著者 Thomas, C.J, Du, X, Li, P, Wang, Y, Ross, E.M, Sprang, S.R. 登録日 2004-03-29 公開日 2004-06-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein {alpha}-subunit. Proc.Natl.Acad.Sci.USA, 101, 2004
1TAD	GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- 分子名称: CACODYLATE ION, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sondek, J, Lambright, D.G, Noel, J.P, Hamm, H.E, Sigler, P.B. 登録日 1995-01-05 公開日 1995-05-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature, 372, 1994

 

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