7U9V
| Integrin alaphIIBbeta3 complex with BMS4-1 | Descriptor: | (4-{[(5S)-3-(4-carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 light chain, ... | Authors: | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-11 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.25492167 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UDG
| Integrin alaphIIBbeta3 complex with lotrafiban | Descriptor: | 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-19 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.800069 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7TMZ
| Integrin alaphIIBbeta3 complex with BMS compound 4 | Descriptor: | (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | Deposit date: | 2022-01-20 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.20002 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UDH
| Integrin alaphIIBbeta3 complex with BMS4-3 | Descriptor: | (4-{[(5S)-3-(piperidin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 Fab light chain, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-19 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.99998844 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7U9F
| Integrin alaphIIBbeta3 complex with BMS compound 4 in Mn2+ | Descriptor: | (4-{[(5S)-3-{4-[(E)-imino(4-methylpiperazin-1-yl)methyl]phenyl}-4,5-dihydro-1,2-oxazol-5-yl]methyl}piperazin-1-yl)acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-10 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.70000529 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UFH
| Integrin alaphIIBbeta3 complex with fradafiban (Mn/Ca) | Descriptor: | 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-22 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.99768162 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7TPD
| Integrin alaphIIBbeta3 complex with EF5154 | Descriptor: | (4-{[2-oxo-4-(piperidin-4-yl)piperazin-1-yl]acetyl}phenoxy)acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhu, J, Lin, F.-Y, Zhu, J, Springer, T.A. | Deposit date: | 2022-01-25 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UCY
| Integrin alaphIIBbeta3 complex with gantofiban | Descriptor: | (4-{[(5R)-3-(4-carbamimidoylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}piperazin-1-yl)acetic acid, 10E5 Fab heavy chain, 10E5 Fab light chain, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-17 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.34996319 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UE0
| Integrin alaphIIBbeta3 complex with fradafiban | Descriptor: | 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-20 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.741962 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7UBR
| Integrin alaphIIBbeta3 complex with GR144053 | Descriptor: | 10E5 Fab heavy chain, 10E5 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lin, F.-Y, Zhu, J, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-15 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.04992747 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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7U60
| Integrin alaphIIBbeta3 complex with cRGDfV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARG-GLY-ASP-DPN-VAL, ... | Authors: | Zhu, J, Lin, F.Y, Zhu, J, Springer, T.A. | Deposit date: | 2022-03-03 | Release date: | 2022-08-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
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5NEU
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4MMX
| Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | Deposit date: | 2013-09-09 | Release date: | 2014-03-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.32 Å) | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
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7P2D
| Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Jensen, R.K, Andersen, G.R. | Deposit date: | 2021-07-05 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into the function-modulating effects of nanobody binding to the integrin receptor alpha M beta 2. J.Biol.Chem., 298, 2022
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7CEC
| Structure of alpha6beta1 integrin in complex with laminin-511 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Arimori, T, Miyazaki, N, Takagi, J. | Deposit date: | 2020-06-22 | Release date: | 2021-06-23 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural mechanism of laminin recognition by integrin. Nat Commun, 12, 2021
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6BXJ
| Structure of a single-chain beta3 integrin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera protein of Integrin beta-3 and Integrin alpha-L, MAGNESIUM ION | Authors: | Thinn, A.M.M, Wang, Z, Zhou, D, Zhao, Y, Curtis, B.R, Zhu, J. | Deposit date: | 2017-12-18 | Release date: | 2018-10-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.092 Å) | Cite: | Autonomous conformational regulation of beta3integrin and the conformation-dependent property of HPA-1a alloantibodies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8GCD
| Full length Integrin AlphaIIbBeta3 in inactive state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huo, T, Wu, H, Wang, Z. | Deposit date: | 2023-03-01 | Release date: | 2024-03-06 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 2024
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8GCE
| The Extracellular Domain of Integrin AlphaIIbBeta3 in Intermediate State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Huo, T, Wu, H, Wang, Z. | Deposit date: | 2023-03-01 | Release date: | 2024-03-06 | Last modified: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Full-length alpha IIb beta 3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture. Structure, 2024
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6CKB
| Crystal structure of an extended beta3 integrin P33 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Chimera protein of Integrin beta-3 and Integrin alpha-L, ... | Authors: | Zhou, D, Zhu, J. | Deposit date: | 2018-02-27 | Release date: | 2018-08-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of an extended beta3integrin. Blood, 132, 2018
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5NER
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5NET
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5NEM
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7LA4
| Integrin AlphaIIbBeta3-PT25-2 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Bush, M.W, Walz, T, Coller, B, Filizola, M, Spasic, A, Nesic, D, Li, J. | Deposit date: | 2021-01-05 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin alpha IIb beta 3 for ligand binding. Blood Adv, 5, 2021
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7NWL
| Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Integrin alpha-5, ... | Authors: | Schumacher, S, Dedden, D, Vazquez Nunez, R, Matoba, K, Takagi, J, Biertumpfel, C, Mizuno, N. | Deposit date: | 2021-03-17 | Release date: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7, 2021
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5ES4
| RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Sen, M, Springer, T.A. | Deposit date: | 2015-11-16 | Release date: | 2016-03-02 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops. Proc.Natl.Acad.Sci.USA, 113, 2016
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