5ES4

RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION

Summary for 5ES4

Entry DOI	10.2210/pdb5es4/pdb
Descriptor	Integrin alpha-X, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (18 entities in total)
Functional Keywords	complement receptor-4 alphaxbeta2, cell adhesion
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	847070.69
Authors	Sen, M.,Springer, T.A. (deposition date: 2015-11-16, release date: 2016-03-02, Last modification date: 2022-03-23)
Primary citation	Sen, M.,Springer, T.A. Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops. Proc.Natl.Acad.Sci.USA, 113:2940-2945, 2016 Cited by PubMed: 26936951 DOI: 10.1073/pnas.1601379113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation