7EGA
 
 | | TFIID-based intermediate PIC on PUMA promoter | | Descriptor: | DNA (85-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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7ENC
 | | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Qi, Y, Wang, X, Wu, Z, Yin, X, Li, J, Liu, W, Xu, Y. | | Deposit date: | 2021-04-16 | | Release date: | 2021-05-26 | | Last modified: | 2021-06-16 | | Method: | ELECTRON MICROSCOPY (4.13 Å) | | Cite: | Structures of the human Mediator and Mediator-bound preinitiation complex.
Science, 372, 2021
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8GXS
 | | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | | Deposit date: | 2022-09-21 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
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6F44
 | | RNA Polymerase III closed complex CC2. | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. | | Deposit date: | 2017-11-29 | | Release date: | 2018-01-17 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Molecular mechanism of promoter opening by RNA polymerase III.
Nature, 553, 2018
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6F41
 | | RNA Polymerase III initially transcribing complex | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. | | Deposit date: | 2017-11-29 | | Release date: | 2018-01-17 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular mechanism of promoter opening by RNA polymerase III.
Nature, 553, 2018
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5FYW
 | | Transcription initiation complex structures elucidate DNA opening (OC) | | Descriptor: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | | Authors: | Plaschka, C, Hantsche, M, Dienemann, C, Burzinski, C, Plitzko, J, Cramer, P. | | Deposit date: | 2016-03-10 | | Release date: | 2016-05-18 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.35 Å) | | Cite: | Transcription Initiation Complex Structures Elucidate DNA Opening
Nature, 533, 2016
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7NVR
 | | Human Mediator with RNA Polymerase II Pre-initiation complex | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Rengachari, S, Schilbach, S, Aibara, S, Cramer, P. | | Deposit date: | 2021-03-15 | | Release date: | 2021-05-05 | | Last modified: | 2021-06-16 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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6CNF
 | | Yeast RNA polymerase III elongation complex | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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7EDX
 | | p53-bound TFIID-based core PIC on HDM2 promoter | | Descriptor: | DNA (84-mer), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-17 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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5OQJ
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | | Descriptor: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | | Deposit date: | 2017-08-11 | | Release date: | 2018-04-25 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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6GYL
 | | Structure of a yeast closed complex with distorted DNA (core CCdist) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Dienemann, C, Schwalb, B, Schilbach, S, Cramer, P. | | Deposit date: | 2018-06-30 | | Release date: | 2018-12-05 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Promoter Distortion and Opening in the RNA Polymerase II Cleft.
Mol. Cell, 73, 2019
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7LBM
 | | Structure of the human Mediator-bound transcription pre-initiation complex | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Abdella, R, Talyzina, A, He, Y. | | Deposit date: | 2021-01-08 | | Release date: | 2021-03-24 | | Last modified: | 2021-04-14 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structure of the human Mediator-bound transcription preinitiation complex.
Science, 372, 2021
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6CND
 | | Yeast RNA polymerase III natural open complex (nOC) | | Descriptor: | DNA (71-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Han, Y, He, Y. | | Deposit date: | 2018-03-08 | | Release date: | 2018-08-22 | | Last modified: | 2020-01-08 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural visualization of RNA polymerase III transcription machineries.
Cell Discov, 4, 2018
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8GXQ
 | | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | | Deposit date: | 2022-09-21 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (5.04 Å) | | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex.
Science, 378, 2022
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6GYK
 | | Structure of a yeast closed complex (core CC1) | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Dienemann, C, Schwalb, B, Schilbach, S, Cramer, P. | | Deposit date: | 2018-06-30 | | Release date: | 2018-12-05 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Promoter Distortion and Opening in the RNA Polymerase II Cleft.
Mol. Cell, 73, 2019
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7Z7N
 | | Mot1E1434Q:TBP:DNA - substrate recognition state | | Descriptor: | DNA (36-MER), Helicase-like protein, Putative tata-box binding protein | | Authors: | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | | Deposit date: | 2022-03-16 | | Release date: | 2023-03-29 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
Nat.Struct.Mol.Biol., 30, 2023
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5IYA
 | | Human core-PIC in the closed state | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | | Authors: | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | | Deposit date: | 2016-03-24 | | Release date: | 2016-05-18 | | Last modified: | 2019-11-20 | | Method: | ELECTRON MICROSCOPY (5.4 Å) | | Cite: | Near-atomic resolution visualization of human transcription promoter opening.
Nature, 533, 2016
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8WAK
 | | Structure of transcribing complex 2 (TC2), the initially transcribing complex with Pol II positioned 2nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (5.47 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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6F42
 | | RNA Polymerase III closed complex CC1. | | Descriptor: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | Authors: | Vorlaender, M.K, Khatter, H, Wetzel, R, Hagen, W.J.H, Mueller, C.W. | | Deposit date: | 2017-11-29 | | Release date: | 2018-01-17 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Molecular mechanism of promoter opening by RNA polymerase III.
Nature, 553, 2018
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5OQM
 | | STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | Authors: | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | | Deposit date: | 2017-08-13 | | Release date: | 2018-05-09 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Structures of transcription pre-initiation complex with TFIIH and Mediator.
Nature, 551, 2017
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8WAP
 | | Structure of transcribing complex 6 (TC6), the initially transcribing complex with Pol II positioned 6nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (5.85 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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5FMF
 | | the P-lobe of RNA polymerase II pre-initiation complex | | Descriptor: | DNA REPAIR HELICASE RAD25, SSL2, DNA REPAIR HELICASE RAD3, ... | | Authors: | Murakami, K, Tsai, K, Kalisman, N, Bushnell, D.A, Asturias, F.J, Kornberg, R.D. | | Deposit date: | 2015-11-03 | | Release date: | 2015-11-25 | | Last modified: | 2017-07-12 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | Structure of an RNA Polymerase II Pre-Initiation Complex
Proc.Natl.Acad.Sci.USA, 112, 2015
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8WAN
 | | Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-07 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.07 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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8WAS
 | | Structure of transcribing complex 9 (TC9), the initially transcribing complex with Pol II positioned 9nt downstream of TSS. | | Descriptor: | Alpha-amanitin, CDK-activating kinase assembly factor MAT1, DNA-directed RNA polymerase II subunit E, ... | | Authors: | Chen, X, Liu, W, Wang, Q, Wang, X, Ren, Y, Qu, X, Li, W, Xu, Y. | | Deposit date: | 2023-09-08 | | Release date: | 2023-12-06 | | Last modified: | 2024-01-03 | | Method: | ELECTRON MICROSCOPY (6.13 Å) | | Cite: | Structural visualization of transcription initiation in action.
Science, 382, 2023
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7EG7
 | | TFIID-based core PIC on SCP promoter | | Descriptor: | DNA (79-MER), DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ... | | Authors: | Chen, X, Qi, Y, Hou, H, Wang, X, Wu, Z, Li, J, Xu, Y. | | Deposit date: | 2021-03-24 | | Release date: | 2021-05-05 | | Last modified: | 2021-05-19 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | Structural insights into preinitiation complex assembly on core promoters.
Science, 372, 2021
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