3W6Q
| Crystal structure of melB apo-protyrosinase from Asperugillus oryzae | Descriptor: | tyrosinase | Authors: | Fujieda, N, Yabuta, S, Ikeda, T, Oyama, T, Muraki, N, Kurisu, G, Itoh, S. | Deposit date: | 2013-02-20 | Release date: | 2013-06-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Crystal structures of copper-depleted and copper-bound fungal pro-tyrosinase: insights into endogenous cysteine-dependent copper incorporation. J.Biol.Chem., 288, 2013
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3W6W
| Crystal structure of melB holo-protyrosinase from Asperugillus oryzae | Descriptor: | COPPER (II) ION, Tyrosinase | Authors: | Fujieda, N, Yabuta, S, Ikeda, T, Oyama, T, Muraki, N, Kurisu, G, Itoh, S. | Deposit date: | 2013-02-22 | Release date: | 2013-06-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.394 Å) | Cite: | Crystal structures of copper-depleted and copper-bound fungal pro-tyrosinase: insights into endogenous cysteine-dependent copper incorporation. J.Biol.Chem., 288, 2013
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4BED
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4P6S
| Crystal Structure of tyrosinase from Bacillus megaterium with L-DOPA in the active site | Descriptor: | 3,4-DIHYDROXYPHENYLALANINE, Tyrosinase, ZINC ION | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4P6R
| Crystal Structure of tyrosinase from Bacillus megaterium with tyrosine in the active site | Descriptor: | TYROSINE, Tyrosinase, ZINC ION | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4P6T
| Crystal Structure of tyrosinase from Bacillus megaterium with p-tyrosol in the active site | Descriptor: | 4-(2-hydroxyethyl)phenol, COPPER (II) ION, Tyrosinase | Authors: | Goldfeder, M, Kanteev, M, Adir, N, Fishman, A. | Deposit date: | 2014-03-25 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins. Nat Commun, 5, 2014
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4Z0Z
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4Z11
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4Z12
| Recombinantly expressed latent aurone synthase (polyphenol oxidase) co-crystallized with hexatungstotellurate(VI) | Descriptor: | 6-tungstotellurate(VI), Aurone synthase, COPPER (II) ION, ... | Authors: | Molitor, C, Mauracher, S.G, Rompel, A. | Deposit date: | 2015-03-26 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. Proc.Natl.Acad.Sci.USA, 113, 2016
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4Z13
| Recombinantly expressed latent aurone synthase (polyphenol oxidase) co-crystallized with hexatungstotellurate(VI) and soaked in H2O2 | Descriptor: | 6-tungstotellurate(VI), Aurone synthase, COPPER (II) ION, ... | Authors: | Molitor, C, Mauracher, S.G, Rompel, A. | Deposit date: | 2015-03-26 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. Proc.Natl.Acad.Sci.USA, 113, 2016
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4Z10
| Inactive aurone synthase (polyphenol oxidase) co-crystallized with 1,4-resorcinol | Descriptor: | ACETATE ION, Aurone synthase, COPPER (II) ION, ... | Authors: | Molitor, C, Mauracher, S.G, Rompel, A. | Deposit date: | 2015-03-26 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Inactive aurone synthase (polyphenol oxidase) co-crystallized with 1,4-resorcinol To Be Published
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4Z0Y
| Active aurone synthase (polyphenol oxidase), copper B : sulfohistidine ~ 1.4 : 1 | Descriptor: | Aurone synthase, COPPER (II) ION, GLYCEROL | Authors: | Molitor, C, Mauracher, S.G, Rompel, A. | Deposit date: | 2015-03-26 | Release date: | 2016-04-06 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases. Proc.Natl.Acad.Sci.USA, 113, 2016
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4Z14
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5CE9
| structure of tyrosinase from walnut (Juglans regia) | Descriptor: | COPPER (II) ION, OXYGEN ATOM, Polyphenol oxidase, ... | Authors: | Bijelic, A, Pretzler, M, Zekiri, F, Rompel, A. | Deposit date: | 2015-07-06 | Release date: | 2015-10-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Structure of a Plant Tyrosinase from Walnut Leaves Reveals the Importance of """"Substrate-Guiding Residues"""" for Enzymatic Specificity. Angew.Chem.Int.Ed.Engl., 54, 2015
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5I3A
| Crystal Structure of tyrosinase from Bacillus megaterium with configuration A of hydroquinone inhibitor in the active site | Descriptor: | Tyrosinase, ZINC ION, benzene-1,4-diol | Authors: | Kanteev, M, Deri, B, Adir, N, Fishman, A. | Deposit date: | 2016-02-10 | Release date: | 2016-10-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The unravelling of the complex pattern of tyrosinase inhibition. Sci Rep, 6, 2016
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5I3B
| Crystal Structure of tyrosinase from Bacillus megaterium with configuration B of hydroquinone inhibitor in the active site | Descriptor: | Tyrosinase, ZINC ION, benzene-1,4-diol | Authors: | Kanteev, M, Deri, B, Adir, N, Fishman, A. | Deposit date: | 2016-02-10 | Release date: | 2016-10-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The unravelling of the complex pattern of tyrosinase inhibition. Sci Rep, 6, 2016
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5I38
| Crystal Structure of tyrosinase from Bacillus megaterium with inhibitor kojic acid in the active site | Descriptor: | 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE, COPPER (II) ION, Tyrosinase | Authors: | Kanteev, M, Goldfeder, M, Deri, B, Adir, N, Fishman, A. | Deposit date: | 2016-02-10 | Release date: | 2016-10-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The unravelling of the complex pattern of tyrosinase inhibition. Sci Rep, 6, 2016
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5M6B
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5M8N
| Crystal structure of human tyrosinase related protein 1 in complex with mimosine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8M
| Crystal structure of human tyrosinase related protein 1 in complex with kojic acid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8Q
| Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with kojic acid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8P
| Crystal structure of human tyrosinase related protein 1 in complex with tyrosine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2022-12-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8O
| Crystal structure of human tyrosinase related protein 1 in complex with tropolone | Descriptor: | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8T
| Crystal structure of human tyrosinase related protein 1 (T391V-R374S-Y362F) in complex with tropolone | Descriptor: | 2-HYDROXYCYCLOHEPTA-2,4,6-TRIEN-1-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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5M8L
| Crystal structure of human tyrosinase related protein 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lai, X, Soler-Lopez, M, Wichers, H.J, Dijkstra, B.W. | Deposit date: | 2016-10-29 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. Engl., 56, 2017
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