PDB: 608 resultsInfo pagesStatus searchChemie searchBIRD

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6GKF	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139 Descriptor: 14-3-3 protein gamma, Caspase-2 Authors: Alblova, M, Obsil, T, Obsilova, V. Deposit date: 2018-05-20 Release date: 2018-10-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.598 Å) Cite: 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
3M50	Structure of the 14-3-3/PMA2 complex stabilized by Epibestatin Descriptor: 14-3-3-like protein C, N-[(2R,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, N.plumbaginifolia H+-translocating ATPase mRNA Authors: Ottmann, C, Rose, R, Waldmann, H. Deposit date: 2010-03-12 Release date: 2010-05-26 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification and structure of small-molecule stabilizers of 14-3-3 protein-protein interactions Angew.Chem.Int.Ed.Engl., 49, 2010
1O9E	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
1O9C	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
2C1J	Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3 Descriptor: 14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE Authors: Welburn, J.P.I, Macdonald, N, Noble, M.E.M, Nguyen, A, Yaffe, M.B, Clynes, D, Moggs, J.G, Orphanides, G, Thomson, S, Edmunds, J.W, Clayton, A.L, Endicott, J.A, Mahadevan, L.C. Deposit date: 2005-09-15 Release date: 2005-11-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3. Mol.Cell, 20, 2005
5IQP	14-3-3 PROTEIN TAU ISOFORM Descriptor: 14-3-3 protein theta, SULFATE ION Authors: Xiao, B, Smerdon, S.J, Gamblin, S.J. Deposit date: 2016-03-11 Release date: 2016-03-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.602 Å) Cite: Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways Nature, 376, 1995
6T5F	Human 14-3-3 sigma fused to the StARD1 peptide including phosphoserine-195 Descriptor: 14-3-3 protein sigma, StARD1 peptide Authors: Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. Deposit date: 2019-10-16 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family. Febs J., 287, 2020
6KZH	14-3-3 protein in Complex with CIC S173 phosphorylated peptide Descriptor: 14-3-3 protein theta, CIC pS173 peptide Authors: Wen, Y, Shao, Y. Deposit date: 2019-09-24 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.645 Å) Cite: 14-3-3 protein in Complex with CIC S173 phosphorylated peptide To Be Published
7QIP	SARS-CoV-2 Nucleocapsid phosphopeptide 201-210 bound to human 14-3-3 sigma Descriptor: 14-3-3 protein sigma, ARG-GLY-TPO-SER-PRO-ALA-ARG-MET, CHLORIDE ION Authors: Sluchanko, N.N, Tugaeva, K.V, Smith, J.L.R, Antson, A.A. Deposit date: 2021-12-15 Release date: 2021-12-29 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.65 Å) Cite: SARS-CoV-2 Nucleocapsid phosphopeptide 193-200 bound to human 14-3-3 sigma To Be Published
2C23	14-3-3 Protein Beta (Human) in complex with exoenzyme S peptide Descriptor: 14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE Authors: Elkins, J.M, Schoch, G.A, Yang, X, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. Deposit date: 2005-09-26 Release date: 2005-09-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
6BZD	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide Descriptor: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, GlcNAcylated peptide Authors: Schumacher, M.A. Deposit date: 2017-12-22 Release date: 2018-05-09 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EWW	Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif Descriptor: 14-3-3 protein zeta/delta, ARG-LYS-LEU-SEP-LEU-GLN-GLU-ARG Authors: Lentini Santo, D, Obsilova, V, Obsil, T. Deposit date: 2017-11-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.679 Å) Cite: 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling. To Be Published
2C74	14-3-3 Protein Eta (Human) Complexed to Peptide Descriptor: 14-3-3 PROTEIN ETA, CITRIC ACID, CONSENSUS PEPTIDE MODE 1 FOR 14-3-3 PROTEINS Authors: Elkins, J.M, Yang, X, Smee, C.E.A, Johansson, C, Sundstrom, M, Edwards, A, Weigelt, J, Arrowsmith, C, Doyle, D.A. Deposit date: 2005-11-17 Release date: 2005-12-02 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc. Natl. Acad. Sci. U.S.A., 103, 2006
8DGP	14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... Authors: Roy, M.J, Hardy, J.M, Lucet, I.S. Deposit date: 2022-06-24 Release date: 2023-06-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
7A6R	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif Descriptor: 14-3-3 protein gamma, DAPK2 C-terminal peptide Authors: Horvath, M, Obsilova, V, Obsil, T. Deposit date: 2020-08-26 Release date: 2021-08-25 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
6EIH	The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide Descriptor: 14-3-3 protein epsilon, SER-ILE-SEP-ARG Authors: Akutsu, M, Wagner, S.A, Beli, P. Deposit date: 2017-09-19 Release date: 2018-02-14 Last modified: 2019-10-16 Method: X-RAY DIFFRACTION (2.7 Å) Cite: p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage. Nat Commun, 9, 2018
1IB1	CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX Descriptor: 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE Authors: Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F. Deposit date: 2001-03-26 Release date: 2001-05-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell(Cambridge,Mass.), 105, 2001
1O9F	Structural view of a fungal toxin acting on a 14-3-3 regulatory complex Descriptor: 14-3-3-LIKE PROTEIN C, FUSICOCCIN, PLASMA MEMBRANE H+ ATPASE Authors: Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C. Deposit date: 2002-12-12 Release date: 2003-03-06 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex Embo J., 22, 2003
2O98	Structure of the 14-3-3 / H+-ATPase plant complex Descriptor: 14-3-3-like protein C, FUSICOCCIN, Plasma membrane H+ ATPase, ... Authors: Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. Deposit date: 2006-12-13 Release date: 2007-04-03 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy Mol.Cell, 25, 2007
5D3F	Crystal structure of human 14-3-3 zeta in complex with CFTR R-domain peptide pS753-pS768 and stabilizer fusicoccin-A Descriptor: 14-3-3 protein zeta/delta, Cystic fibrosis transmembrane conductance regulator, FUSICOCCIN Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2019-03-13 Method: X-RAY DIFFRACTION (2.74 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
6YOS	Binary complex of 14-3-3 zeta with Glucocorticoid Receptor (GR) pT524 pS617 peptide Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor,Glucocorticoid receptor Authors: Munier, C.C, Edman, K, Perry, M.W.D, Ottmann, C. Deposit date: 2020-04-15 Release date: 2021-03-24 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators. J.Biol.Chem., 296, 2021
5D3E	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795 Descriptor: 14-3-3 protein gamma, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Leysen, S.F.R, Ottmann, C. Deposit date: 2015-08-06 Release date: 2016-03-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR. Proc.Natl.Acad.Sci.USA, 113, 2016
7EXE	Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide Descriptor: 14-3-3 protein zeta/delta, Disintegrin and metalloproteinase domain-containing protein 22 Authors: Yan, L, Okatsu, K, Fukai, S. Deposit date: 2021-05-27 Release date: 2021-11-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.75 Å) Cite: LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice Cell Rep, 2021
6SAD	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164 Descriptor: 14-3-3 protein gamma, Caspase-2 Authors: Kalabova, D, Obsil, T, Obsilova, V. Deposit date: 2019-07-16 Release date: 2020-01-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.753 Å) Cite: 14-3-3 protein binding blocks the dimerization interface of caspase-2. Febs J., 287, 2020

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