6EWW

Structure of 14-3-3 zeta in complex with CaMKK2 14-3-3 binding motif

Summary for 6EWW

Entry DOI	10.2210/pdb6eww/pdb
Descriptor	14-3-3 protein zeta/delta, ARG-LYS-LEU-SEP-LEU-GLN-GLU-ARG (3 entities in total)
Functional Keywords	14-3-3 protein, calcium/calmodulin-dependent protein kinase kinase 2, camkk2, phosphorylation, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm : P63104
Total number of polymer chains	8
Total formula weight	110496.64
Authors	Lentini Santo, D.,Obsilova, V.,Obsil, T. (deposition date: 2017-11-06, release date: 2017-11-15, Last modification date: 2024-01-17)
Primary citation	Psenakova, K.,Petrvalska, O.,Kylarova, S.,Lentini Santo, D.,Kalabova, D.,Herman, P.,Obsilova, V.,Obsil, T. 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862:1612-1625, 2018 Cited by PubMed: 29649512 DOI: 10.1016/j.bbagen.2018.04.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.679 Å)

Structure validation