6W2B
| Anomalous bromine signal reveals the position of Br-paroxetine complexed with the serotonin transporter at the central site | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, ... | 著者 | Coleman, J.A, Navratna, V, Yang, D. | 登録日 | 2020-03-05 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (4.7 Å) | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
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3GWU
| Leucine transporter LeuT in complex with sertraline | 分子名称: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ... | 著者 | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | 登録日 | 2009-04-01 | 公開日 | 2009-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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6W2C
| Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site | 分子名称: | 8B6 heavy chain antibody fragment, 8B6 light chain antibody fragment, I-paroxetine, ... | 著者 | Coleman, J.A, Navratna, V, Yang, D. | 登録日 | 2020-03-05 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (6.3 Å) | 主引用文献 | Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, 2020
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3GWW
| Leucine transporter LeuT in complex with S-fluoxetine | 分子名称: | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | 著者 | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | 登録日 | 2009-04-01 | 公開日 | 2009-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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3GJD
| Crystal Structure of LeuT with bound OG | 分子名称: | CHLORIDE ION, LEUCINE, SODIUM ION, ... | 著者 | Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. | 登録日 | 2009-03-08 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation Proc.Natl.Acad.Sci.USA, 106, 2009
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3GJC
| Crystal Structure of the E290S mutant of LeuT with bound OG | 分子名称: | LEUCINE, SODIUM ION, Transporter, ... | 著者 | Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. | 登録日 | 2009-03-08 | 公開日 | 2009-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation Proc.Natl.Acad.Sci.USA, 106, 2009
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7LWD
| Cryo-EM structure of the wild-type human serotonin transporter complexed with vilazodone, imipramine and 15B8 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, ... | 著者 | Yang, D, Kalenderoglou, I.E, Gouaux, E, Coleman, J.A, Loland, C.J. | 登録日 | 2021-03-01 | 公開日 | 2021-08-11 | 最終更新日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nat Commun, 12, 2021
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7LI9
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7LIA
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7LI7
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7LI6
| apo SERT reconstituted in lipid nanodisc in KCl | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | 著者 | Yang, D, Gouaux, E. | 登録日 | 2021-01-26 | 公開日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Illumination of serotonin transporter mechanism and role of the allosteric site. Sci Adv, 7, 2021
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7LI8
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7Y7Y
| Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom | 分子名称: | (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7Z
| Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7W
| Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7V
| Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1 | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7DJ1
| Crystal structure of the G26C mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.528 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DII
| Crystal structure of LeuT in lipidic cubic phase at pH 7 | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DJ2
| Crystal structure of the G26C/E290S mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DIX
| Crystal structure of LeuT in lipidic cubic phase at pH 5 | 分子名称: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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7DJC
| Crystal structure of the G26C/Q250A mutant of LeuT | 分子名称: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | 著者 | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | 登録日 | 2020-11-20 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states. J.Biol.Chem., 296, 2021
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3F3A
| Crystal Structure of LeuT bound to L-Tryptophan and Sodium | 分子名称: | SODIUM ION, TETRADECANE, TRYPTOPHAN, ... | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | 登録日 | 2008-10-30 | 公開日 | 2008-12-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F3D
| Crystal structure of LeuT bound to L-Methionine and sodium | 分子名称: | METHIONINE, SODIUM ION, Transporter, ... | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | 登録日 | 2008-10-30 | 公開日 | 2008-12-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F4I
| Crystal Structure of LeuT bound to L-selenomethionine and sodium | 分子名称: | SELENOMETHIONINE, SODIUM ION, Transporter, ... | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | 登録日 | 2008-10-31 | 公開日 | 2008-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F3E
| Crystal structure of LeuT bound to L-leucine (30 mM) and sodium | 分子名称: | LEUCINE, SODIUM ION, Transporter, ... | 著者 | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | 登録日 | 2008-10-30 | 公開日 | 2008-12-23 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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