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7QIV
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BU of 7qiv by Molmil
Structure of human C3b in complex with the EWE nanobody
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
著者Pedersen, H, Andersen, G.R.
登録日2021-12-16
公開日2022-02-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Front Immunol, 13, 2022
3G6J
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BU of 3g6j by Molmil
C3b in complex with a C3b specific Fab
分子名称: CALCIUM ION, Complement C3 alpha chain, Complement C3 beta chain, ...
著者Wiesmann, C.
登録日2009-02-06
公開日2009-03-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
J.Biol.Chem., 284, 2009
5HCC
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BU of 5hcc by Molmil
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3.
分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Jore, M.M, Johnson, S, Lea, S.M.
登録日2016-01-04
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCD
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Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ...
著者Jore, M.M, Johnson, S, Lea, S.M.
登録日2016-01-04
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCE
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Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, Complement C5, ...
著者Jore, M.M, Johnson, S, Lea, S.M.
登録日2016-01-04
公開日2016-03-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5I5K
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BU of 5i5k by Molmil
Structure of complement C5 in complex with eculizumab
分子名称: Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain), ...
著者Schatz-Jakobsen, J.A, Andersen, G.R.
登録日2016-02-15
公開日2016-03-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
J Immunol., 197, 2016
5JTW
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BU of 5jtw by Molmil
Crystal structure of complement C4b re-refined using iMDFF
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A
著者Croll, T.I, Andersen, G.R.
登録日2016-05-09
公開日2016-08-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
5JPN
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Structure of human complement C4 rebuilt using iMDFF
分子名称: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C4-A, ...
著者Croll, T.I, Andersen, G.R.
登録日2016-05-03
公開日2016-08-10
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.
Acta Crystallogr D Struct Biol, 72, 2016
3KLS
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BU of 3kls by Molmil
Structure of complement C5 in complex with SSL7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
登録日2009-11-09
公開日2009-11-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3KM9
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BU of 3km9 by Molmil
Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ...
著者Laursen, N.S, Gordon, N, Hermans, S, Lorenz, N, Jackson, N, Wines, B, Spillner, E, Christensen, J.B, Jensen, M, Fredslund, F, Bjerre, M, Sottrup-Jensen, L, Fraser, J.D, Andersen, G.R.
登録日2009-11-10
公開日2009-12-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
3L3O
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BU of 3l3o by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3c
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor
著者Geisbrecht, B.V, Garcia, B.G.
登録日2009-12-17
公開日2010-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.405 Å)
主引用文献Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3L5N
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BU of 3l5n by Molmil
Staphylococcal Complement Inhibitor (SCIN) in complex with Human Complement Component C3b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Staphylococcal complement inhibitor, ...
著者Geisbrecht, B.V, Garcia, B.L.
登録日2009-12-22
公開日2010-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (7.536 Å)
主引用文献Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
7VOO
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BU of 7voo by Molmil
Induced alpha-2-macroglobulin monomer
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Huang, X, Wang, Y, Ping, Z.
登録日2021-10-14
公開日2022-10-19
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7VON
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BU of 7von by Molmil
Native alpha-2-macroglobulin monomer
分子名称: Alpha-2-macroglobulin
著者Huang, X, Wang, Y.
登録日2021-10-14
公開日2022-11-16
最終更新日2022-12-07
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7ZGJ
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BU of 7zgj by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7ZGK
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Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
分子名称: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ...
著者Suelzen, H, Zoll, S.
登録日2022-04-03
公開日2023-04-05
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
8AYH
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BU of 8ayh by Molmil
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
分子名称: 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid, Cobra venom factor, Complement C5 alpha chain, ...
著者Srinivas, H.
登録日2022-09-02
公開日2022-12-21
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献A small-molecule inhibitor of C5 complement protein.
Nat.Chem.Biol., 15, 2019
7OP0
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BU of 7op0 by Molmil
Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain.
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ...
著者Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R.
登録日2021-05-28
公開日2022-04-06
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献The Chemical Synthesis of Knob Domain Antibody Fragments.
Acs Chem.Biol., 16, 2021
7O7O
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BU of 7o7o by Molmil
(h-alpha2M)4 semiactivated II state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7S
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(h-alpha2M)4 plasmin-activated II state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7M
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(h-alpha2M)4 native II
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7R
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BU of 7o7r by Molmil
(h-alpha2M)4 plasmin-activated I state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7N
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(h-alpha2M)4 semiactivated I state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (7.3 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7Q
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BU of 7o7q by Molmil
(h-alpha2M)4 trypsin-activated state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022
7O7P
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BU of 7o7p by Molmil
(h-alpha2M)4 activated state
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin
著者Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R.
登録日2021-04-13
公開日2022-04-13
最終更新日2022-05-11
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin.
Proc.Natl.Acad.Sci.USA, 119, 2022

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