4H0N
 
 | | Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant | | 分子名称: | CALCIUM ION, DNMT2, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Li, S, Du, J, Yang, H, Yin, J, Zhong, J, Ding, J. | | 登録日 | 2012-09-09 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.712 Å) | | 主引用文献 | Functional and structural characterization of DNMT2 from Spodoptera frugiperda.
J Mol Cell Biol, 5, 2013
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2C7P
 | | HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*G*GP*AP*TP*GP*(5CM*2PR)*CP*TP*GP*AP*C)-3', 5'-D(*G*TP*CP*AP*GP*CP*GP*CP*AP*TP*CP*C)-3', ... | | 著者 | Neely, R.K, Daujotyte, D, Grazulis, S, Magennis, S.W, Dryden, D.T.F, Klimasauskas, S, Jones, A.C. | | 登録日 | 2005-11-25 | | 公開日 | 2005-12-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Time-Resolved Fluorescence of 2-Aminopurine as a Probe of Base Flipping in M.HhaI-DNA Complexes.
Nucleic Acids Res., 33, 2005
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2C7O
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2C7R
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2C7Q
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2Z6A
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2Z6U
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2ZCJ
 | | Ternary structure of the Glu119Gln M.HhaI, C5-Cytosine DNA methyltransferase, with unmodified DNA and AdoHcy | | 分子名称: | DNA (5'-D(*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), DNA (5'-D(*DTP*DGP*DAP*DTP*DAP*DGP*DCP*DGP*DCP*DTP*DAP*DTP*DC)-3'), Modification methylase HhaI, ... | | 著者 | Shieh, F.K, Reich, N.O. | | 登録日 | 2007-11-09 | | 公開日 | 2007-12-04 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | AdoMet-dependent Methyl-transfer: Glu(119) Is Essential for DNA C5-Cytosine Methyltransferase M.HhaI
J.Mol.Biol., 373, 2007
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7L4N
 | | Crystal structure of the DRM2 (C397R)-CCG DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-19 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.247 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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7L4C
 | | Crystal structure of the DRM2-CTT DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*TP*AP*TP*TP*AP*AP*TP*(C49)P*TP*TP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*TP*AP*AP*TP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-18 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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7L4K
 | | Crystal structure of the DRM2-CCG DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*CP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*GP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-19 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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7L4M
 | | Crystal structure of the DRM2-CCT DNA complex | | 分子名称: | DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*CP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-19 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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7L4F
 | | Crystal structure of the DRM2-CAT DNA complex | | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*CP*CP*TP*CP*CP*TP*(C49)P*AP*TP*CP*CP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*GP*GP*AP*TP*GP*AP*GP*GP*AP*GP*GP*AP*AP*T)-3'), ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-19 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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7L4H
 | | Crystal structure of the DRM2-CTG DNA complex | | 分子名称: | DNA (5'-D(*AP*TP*TP*CP*CP*TP*AP*AP*TP*(C49)P*TP*GP*AP*AP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*TP*TP*CP*AP*GP*AP*TP*TP*AP*GP*GP*AP*AP*T)-3'), DNA (cytosine-5)-methyltransferase DRM2, ... | | 著者 | Fang, J, Song, J. | | 登録日 | 2020-12-19 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | Substrate deformation regulates DRM2-mediated DNA methylation in plants.
Sci Adv, 7, 2021
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2Z6Q
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7MHT
 | | CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI/DNA COMPLEX | | 分子名称: | 5'-D(P*CP*CP*AP*TP*GP*AP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3', CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI, ... | | 著者 | O'Gara, M, Horton, J.R, Roberts, R.J, Cheng, X. | | 登録日 | 1998-08-05 | | 公開日 | 1998-11-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | | 主引用文献 | Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base.
Nat.Struct.Biol., 5, 1998
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2HMY
 | | BINARY COMPLEX OF HHAI METHYLTRANSFERASE WITH ADOMET FORMED IN THE PRESENCE OF A SHORT NONPSECIFIC DNA OLIGONUCLEOTIDE | | 分子名称: | PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI), S-ADENOSYLMETHIONINE | | 著者 | O'Gara, M, Zhang, X, Roberts, R.J, Cheng, X. | | 登録日 | 1999-02-08 | | 公開日 | 1999-03-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide.
J.Mol.Biol., 287, 1999
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2HR1
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2I9K
 | | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI | | 分子名称: | 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. | | 登録日 | 2006-09-05 | | 公開日 | 2006-10-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI
J.Mol.Biol., 362, 2006
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8C59
 | | CpG specific M.MpeI methyltransferase crystallized in the presence of 5-bromocytosine (converted to 5mC) and 5-methylcytosine containing dsDNA | | 分子名称: | CARBONATE ION, CITRIC ACID, Cytosine-specific methyltransferase, ... | | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | | 登録日 | 2023-01-06 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors
To Be Published
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8C57
 | | CpG specific M.MpeI methyltransferase crystallized in the presence of 5,6-dihydro-5-azacytosine (converted to 5m-dhaC) and 5-methylcytosine containing dsDNA | | 分子名称: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5MA)P*GP*CP*TP*GP*AP*A)-3'), ... | | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | | 登録日 | 2023-01-06 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors
To Be Published
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8C58
 | | CpG specific M.MpeI methyltransferase crystallized in the presence of 5-hydroxycytosine and 5-methylcytosine containing dsDNA | | 分子名称: | CARBONATE ION, Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5OC)P*GP*CP*TP*GP*AP*A)-3'), ... | | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | | 登録日 | 2023-01-06 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors
To Be Published
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8C56
 | | CpG specific M.MpeI methyltransferase crystallized in the presence of 2'-deoxy-5-methylzebularine (5mZ) and 5-methylcytosine containing dsDNA | | 分子名称: | Cytosine-specific methyltransferase, DNA (5'-D(*CP*CP*AP*CP*AP*TP*GP*(5PY)P*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*TP*G)-3'), ... | | 著者 | Wojciechowski, M, Czapinska, H, Krwawicz, J, Rafalski, D, Bochtler, M. | | 登録日 | 2023-01-06 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Cytosine analogues as DNA methyltransferase substrates and inhibitors
To Be Published
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6W8B
 | | Structure of DNMT3A in complex with CGA DNA | | 分子名称: | CGA DNA (25-MER), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, ... | | 著者 | Anteneh, H, Song, J. | | 登録日 | 2020-03-20 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Nat Commun, 11, 2020
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6W89
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