PDB: 283 resultsInfo pagesStatus searchChemie searchBIRD

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8CN7	Pa.FabF-C164Q in complex with platencin Descriptor: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COU	Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid Descriptor: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-28 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.68 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN5	Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.93 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COV	Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-28 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN4	Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.67 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNE	Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.57 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN8	apo Pseudomonas aeruginosa FabF C164A mutant Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNG	Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN2	Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CG6	The ACP crosslinked to the SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) Descriptor: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide Authors: Munoz-Hernandez, H, Tittes, Y.U, Maier, T. Deposit date: 2023-02-03 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: CryoEM structure of ACP crosslinked to SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) at 3.4 Angstroms resolution To Be Published
8PSL	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASx sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS2	Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSK	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASx sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PRV	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosreductase domain (FASamn sample) Descriptor: COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-12 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSP	Asymmetric unit of the yeast fatty acid synthase in rotated state with ACP at the acetyl transferase domain (FASx sample) Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS8	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the enoyl reductase domain (FASam sample) Descriptor: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-26 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (4 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSA	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASam sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSJ	Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl transferase domain (FASx sample) Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PRW	Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution Descriptor: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, COENZYME A, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-12 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (1.9 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS9	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASam sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS1	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASamn sample) Descriptor: COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSM	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the malonyl/palmitoyl transferase domain (FASx sample) Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSG	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the acetyl transferase domain (FASx sample) Descriptor: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSF	Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl transferase domain (FASx sample) Descriptor: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... Authors: Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. Deposit date: 2023-07-13 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PFZ	Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid Descriptor: (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ... Authors: Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. Deposit date: 2023-06-17 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.78 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023

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