PDB: 729 resultsInfo pagesStatus searchChemie searchBIRD

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4NWF	Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 11 Authors: Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. Deposit date: 2013-12-06 Release date: 2014-12-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of the tyrosine phosphatase SHP-2 with N308D mutation To be Published
4NWG	Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... Authors: Qiu, W, Lin, A, Hutchinson, A, Romanov, V, Ruzanov, M, Thompson, C, Lam, K, Kisselman, G, Battalie, K, Chirgadze, N.Y. Deposit date: 2013-12-06 Release date: 2014-12-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation To be Published
4OHE	LEOPARD Syndrome-Associated SHP2/G464A mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. Deposit date: 2014-01-17 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.506 Å) Cite: Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHD	LEOPARD Syndrome-Associated SHP2/A461T mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. Deposit date: 2014-01-17 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHI	LEOPARD Syndrome-Associated SHP2/Q510E mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. Deposit date: 2014-01-17 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHH	LEOPARD Syndrome-Associated SHP2/Q506P mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. Deposit date: 2014-01-17 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4OHL	LEOPARD Syndrome-Associated SHP2/T468M mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Zhang, R.Y, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L, Liu, S, Zhang, Z.Y. Deposit date: 2014-01-17 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53, 2014
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 Descriptor: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. Deposit date: 2014-03-17 Release date: 2015-04-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-05 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.903 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4QAH	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X. Deposit date: 2014-05-05 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.403 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. Deposit date: 2014-05-08 Release date: 2014-12-24 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.292 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 Authors: Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. Deposit date: 2014-05-08 Release date: 2015-02-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.912 Å) Cite: The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4QUM	Crystal structure of PTPN3 (PTPH1) in complex with a dually phosphorylated MAPK12 peptide Descriptor: Mitogen-activated protein kinase 12, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-10 Release date: 2014-12-10 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.516 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4QUN	Crystal structure of the PTPN3 (PTPH1) catalytic domain C842S mutant Descriptor: GLYCEROL, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.E, Meng, T.C, Wang, A.H.J. Deposit date: 2014-07-11 Release date: 2014-12-10 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Reciprocal allosteric regulation of p38 gamma and PTPN3 involves a PDZ domain-modulated complex formation. Sci.Signal., 7, 2014
4RDD	Co-crystal structure of SHP2 in complex with a Cefsulodin derivative Descriptor: 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 Authors: Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. Deposit date: 2014-09-18 Release date: 2015-07-01 Last modified: 2015-12-16 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
4RH5	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RH9	Crystal structure of PTPN3 (PTPH1) H812F, M883G mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-01 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.598 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RHG	Crystal structure of PTPN3 (PTPH1) D811E, C842S mutant in complex with Eps15 pTyr849 peptide Descriptor: Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-02 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI4	Crystal structure of PTPN3 (PTPH1) Y676I mutant in complex with vanadate Descriptor: Tyrosine-protein phosphatase non-receptor type 3, VANADATE ION Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.596 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4RI5	Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Descriptor: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 3, oxido(dioxo)vanadium Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-10-05 Release date: 2015-03-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4S0G	Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide Descriptor: Peptide from Epidermal growth factor receptor substrate 15, Tyrosine-protein phosphatase non-receptor type 3 Authors: Chen, K.-E, Meng, T.C, Wang, A.H.-J. Deposit date: 2014-12-31 Release date: 2015-03-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.723 Å) Cite: Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23, 2015
4Y14	Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633) Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ... Authors: Choy, M.S, Connors, C, Page, R, Peti, W. Deposit date: 2015-02-06 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.898 Å) Cite: PTP1B inhibition suggests a therapeutic strategy for Rett syndrome. J.Clin.Invest., 125, 2015
4YAA	YopH W354Y Yersinia enterocolitica PTPase apo form Descriptor: ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH Authors: Moise, G.E, Johnson, S.J, Hengge, A.C. Deposit date: 2015-02-17 Release date: 2015-10-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
4Z6B	YopH W354H Yersinia enterocolitica PTPase in the apo form Descriptor: ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase YopH Authors: Moise, G.E, Johnson, S.J, Hengge, A.C. Deposit date: 2015-04-04 Release date: 2015-10-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
4ZI4	YopH W354H Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site Descriptor: Divanadate Glycerol ester, Tyrosine-protein phosphatase YopH, VANADATE ION Authors: Moise, G.E, Johnson, S.J, Hengge, A.C. Deposit date: 2015-04-27 Release date: 2015-10-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.121 Å) Cite: Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015

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