4OHH

LEOPARD Syndrome-Associated SHP2/Q506P mutant

Summary for 4OHH

Entry DOI	10.2210/pdb4ohh/pdb
Related	4OHD 4OHE 4OHI 4OHT
Descriptor	Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
Functional Keywords	sh2 domain, phosphatase domain, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q06124
Total number of polymer chains	1
Total formula weight	61730.63
Authors	Yu, Z.H.,Zhang, R.Y.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Wang, L.,Liu, S.,Zhang, Z.Y. (deposition date: 2014-01-17, release date: 2014-09-24, Last modification date: 2023-09-20)
Primary citation	Yu, Z.H.,Zhang, R.Y.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Liu, S.,Zhang, Z.Y. Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations. Biochemistry, 53:4136-4151, 2014 Cited by PubMed: 24935154 DOI: 10.1021/bi5002695 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation