7BWA
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin | Descriptor: | Insulin fusion, Insulin receptor | Authors: | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | Deposit date: | 2020-04-14 | Release date: | 2021-04-14 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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8K53
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8ODZ
| Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8OE4
| Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | Authors: | Bloch, Y, Felix, J, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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1A22
| HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR | Descriptor: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR | Authors: | De Vos, A.M, Ultsch, M. | Deposit date: | 1998-01-15 | Release date: | 1998-04-29 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J.Mol.Biol., 277, 1998
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5N47
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5N48
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5I99
| Crystal structure of mouse CNTN3 Ig5-Fn2 domains | Descriptor: | Contactin-3, GLYCEROL | Authors: | Nikolaienko, R.M, Bouyain, S. | Deposit date: | 2016-02-19 | Release date: | 2016-08-31 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues. J.Biol.Chem., 291, 2016
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6VWI
| Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain | Authors: | Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. | Deposit date: | 2020-02-19 | Release date: | 2020-05-13 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
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6VWH
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1BQU
| CYTOKYNE-BINDING REGION OF GP130 | Descriptor: | GLYCEROL, PROTEIN (GP130), SULFATE ION | Authors: | Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y. | Deposit date: | 1998-08-18 | Release date: | 1998-08-26 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a cytokine-binding region of gp130. EMBO J., 17, 1998
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1AXI
| STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE | Descriptor: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR, SULFATE ION | Authors: | Atwell, S, Ultsch, M, De Vos, A.M, Wells, J.A. | Deposit date: | 1997-10-15 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural plasticity in a remodeled protein-protein interface. Science, 278, 1997
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6VWJ
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5J7C
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5J12
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6VWG
| Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain | Authors: | Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. | Deposit date: | 2020-02-19 | Release date: | 2020-05-13 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
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5J11
| Structure of human TSLP in complex with TSLPR and IL-7Ralpha | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, ... | Authors: | Verstraete, K, Savvides, S.N. | Deposit date: | 2016-03-28 | Release date: | 2017-04-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. Nat Commun, 8, 2017
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6ZZ8
| MB_CRS6-15 bound to CrSAS-6_6HR | Descriptor: | Centriole protein, Protein B | Authors: | Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P. | Deposit date: | 2020-08-04 | Release date: | 2021-07-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.73 Å) | Cite: | Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly. Nat Commun, 12, 2021
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2XYC
| CRYSTAL STRUCTURE OF NCAM2 IGIV-FN3I | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NEURAL CELL ADHESION MOLECULE 2, ... | Authors: | Kulahin, N, Rasmussen, K.K, Kristensen, O, Berezin, V, Bock, E, Walmod, P.S, Gajhede, M. | Deposit date: | 2010-11-17 | Release date: | 2011-02-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structural Model and Trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule. Structure, 19, 2011
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2X11
| Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain | Descriptor: | EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 | Authors: | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | Deposit date: | 2009-12-21 | Release date: | 2010-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.83 Å) | Cite: | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17, 2010
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7U6E
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7U6D
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7BW7
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | Descriptor: | Insulin fusion, Insulin receptor | Authors: | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | Deposit date: | 2020-04-13 | Release date: | 2021-04-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BW8
| Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | Descriptor: | Insulin fusion, Insulin receptor | Authors: | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | Deposit date: | 2020-04-14 | Release date: | 2021-04-14 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7U23
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