5J11

Structure of human TSLP in complex with TSLPR and IL-7Ralpha

Summary for 5J11

• Entry DOI: 10.2210/pdb5j11/pdb
• Descriptor: Thymic stromal lymphopoietin, Interleukin-7 receptor subunit alpha, Cytokine receptor-like factor 2, ... (6 entities in total)
• Functional Keywords: cytokine inflammation tslp signaling complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 71282.23

Authors

Verstraete, K.,Savvides, S.N. (deposition date: 2016-03-28, release date: 2017-04-05, Last modification date: 2024-01-10)

• Primary citation: Verstraete, K.,Peelman, F.,Braun, H.,Lopez, J.,Van Rompaey, D.,Dansercoer, A.,Vandenberghe, I.,Pauwels, K.,Tavernier, J.,Lambrecht, B.N.,Hammad, H.,De Winter, H.,Beyaert, R.,Lippens, G.,Savvides, S.N.; Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.; Nat Commun, 8:14937-14937, 2017; PubMed: 28368013; DOI: 10.1038/ncomms14937

Experimental method

X-RAY DIFFRACTION (2.56 Å)