4ORZ
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2PZ1
| Crystal Structure of Auto-inhibited Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Betts, L, Sondek, J, Rossman, K.L. | Deposit date: | 2007-05-17 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14, 2007
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2ROL
| Structural Basis of PxxDY motif recognition in SH3 binding | Descriptor: | 12-meric peptide from T-cell surface glycoprotein CD3 epsilon chain, Epidermal growth factor receptor kinase substrate 8-like protein 1 | Authors: | Aitio, O, Hellman, M, Kesti, T, Kleino, I, Samuilova, O, Tossavainen, H, Paakkonen, K, Saksela, K, Permi, P. | Deposit date: | 2008-04-02 | Release date: | 2009-03-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis of PxxDY motif recognition in SH3 binding J.Mol.Biol., 382, 2008
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5NUH
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1AVZ
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1EFN
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1JXM
| CRYSTAL STRUCTURE OF THE GMP BOUND SH3-HOOK-GK FRAGMENT OF PSD-95 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANIDINE, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Tavares, G.A, Panepucci, E.H, Brunger, A.T. | Deposit date: | 2001-09-07 | Release date: | 2002-01-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95. Mol.Cell, 8, 2001
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1JXO
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1K4U
| Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox | Descriptor: | PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX, PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX | Authors: | Kami, K, Takeya, R, Sumimoto, H, Kohda, D. | Deposit date: | 2001-10-08 | Release date: | 2002-04-08 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. EMBO J., 21, 2002
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1KJW
| SH3-Guanylate Kinase Module from PSD-95 | Descriptor: | POSTSYNAPTIC DENSITY PROTEIN 95, SULFATE ION | Authors: | McGee, A.W, Dakoji, S.R, Olsen, O, Bredt, D.S, Lim, W.A, Prehoda, K.E. | Deposit date: | 2001-12-05 | Release date: | 2002-01-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins Mol.Cell, 8, 2001
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1NG2
| Structure of autoinhibited p47phox | Descriptor: | Neutrophil cytosolic factor 1 | Authors: | Groemping, Y, Lapouge, K, Smerdon, S.J, Rittinger, K. | Deposit date: | 2002-12-16 | Release date: | 2003-05-20 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Molecular basis of phosphorylation-induced activation of the NADPH oxidase Cell(Cambridge,Mass.), 113, 2003
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1U5S
| NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain | Descriptor: | Cytoplasmic protein NCK2, PINCH protein, ZINC ION | Authors: | Vaynberg, J, Fukuda, T, Vinogradova, O, Velyvis, A, Ng, L, Wu, C, Qin, J. | Deposit date: | 2004-07-28 | Release date: | 2005-04-05 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility. Mol.Cell, 17, 2005
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1UEC
| Crystal structure of autoinhibited form of tandem SH3 domain of p47phox | Descriptor: | Neutrophil cytosol factor 1 | Authors: | Yuzawa, S, Suzuki, N.N, Fujioka, Y, Ogura, K, Sumimoto, H, Inagaki, F. | Deposit date: | 2003-05-11 | Release date: | 2003-05-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase Genes Cells, 9, 2004
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7CSP
| Structure of Ephexin4 IDPSH | Descriptor: | Rho guanine nucleotide exchange factor 16 | Authors: | Zhang, M, Lin, L, Wang, C, Zhu, J. | Deposit date: | 2020-08-15 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
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7CSR
| Structure of Ephexin4 R676L | Descriptor: | Rho guanine nucleotide exchange factor 16 | Authors: | Zhang, M, Lin, L, Wang, C, Zhu, J. | Deposit date: | 2020-08-17 | Release date: | 2021-02-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
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7CSO
| Structure of Ephexin4 DH-PH-SH3 | Descriptor: | Rho guanine nucleotide exchange factor 16, SULFATE ION | Authors: | Zhang, M, Lin, L, Wang, C, Zhu, J. | Deposit date: | 2020-08-15 | Release date: | 2021-02-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
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1W70
| SH3 domain of p40phox complexed with C-terminal polyProline region of p47phox | Descriptor: | NEUTROPHIL CYTOSOL FACTOR 1, NEUTROPHIL CYTOSOL FACTOR 4, SULFATE ION, ... | Authors: | Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. | Deposit date: | 2004-08-26 | Release date: | 2005-01-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains J.Biol.Chem., 280, 2005
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1YCS
| P53-53BP2 COMPLEX | Descriptor: | 53BP2, P53, ZINC ION | Authors: | Gorina, S, Pavletich, N.P. | Deposit date: | 1996-09-30 | Release date: | 1997-11-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science, 274, 1996
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2DX1
| Crystal structure of RhoGEF protein Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-08-22 | Release date: | 2007-01-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282, 2007
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2DYB
| The crystal structure of human p40(phox) | Descriptor: | Neutrophil cytosol factor 4 | Authors: | Honbou, K. | Deposit date: | 2006-09-08 | Release date: | 2007-01-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. Embo J., 26, 2007
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2JT4
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2KBT
| Attachment of an NMR-invisible solubility enhancement tag (INSET) using a sortase-mediated protein ligation method | Descriptor: | Proto-oncogene vav,Immunoglobulin G-binding protein G | Authors: | Kumeta, H, Kobashigawa, Y, Ogura, K, Inagaki, F. | Deposit date: | 2008-12-07 | Release date: | 2009-02-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method J.Biomol.Nmr, 43, 2009
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2KNB
| Solution NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domain | Descriptor: | E3 ubiquitin-protein ligase parkin, Endophilin-A1 | Authors: | Trempe, J, Guennadi, K, Edna, C.M, Kalle, G. | Deposit date: | 2009-08-20 | Release date: | 2009-12-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol.Cell, 36, 2009
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2L3S
| Structure of the autoinhibited Crk | Descriptor: | Autoinhibited Crk protein | Authors: | Kalodimos, C.G, Sarkar, P, Saleh, T, Tzeng, S.R, Birge, R. | Deposit date: | 2010-09-21 | Release date: | 2010-12-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for regulation of the Crk signaling protein by a proline switch. Nat.Chem.Biol., 7, 2011
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2LZ6
| Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications | Descriptor: | CD2-associated protein, Ubiquitin | Authors: | Ortega-Roldan, J, Azuaga, A, Blackledge, M, Van Nuland, N. | Deposit date: | 2012-09-24 | Release date: | 2013-10-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications. Plos One, 8, 2013
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