4ORZ
HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain
Summary for 4ORZ
Entry DOI | 10.2210/pdb4orz/pdb |
Related | 3RBB 3REA |
Descriptor | Tyrosine-protein kinase HCK, Protein Nef, single domain antibody sdAb19, ... (4 entities in total) |
Functional Keywords | sh3 domain, immunglobolin fold, antibodies, epitopes, hiv antibodies, hiv accessory proteins, pxxp motif, complementarity determining regions, transferase-apoptosis-immune system complex, transferase/apoptosis/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Lysosome. Isoform 2: Cell membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle: P08631 Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407 |
Total number of polymer chains | 3 |
Total formula weight | 37439.97 |
Authors | |
Primary citation | Lulf, S.,Matz, J.,Rouyez, M.C.,Jarviluoma, A.,Saksela, K.,Benichou, S.,Geyer, M. Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody. Retrovirology, 11:24-24, 2014 Cited by PubMed: 24620746DOI: 10.1186/1742-4690-11-24 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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