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4ORZ

HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain

Summary for 4ORZ
Entry DOI10.2210/pdb4orz/pdb
Related3RBB 3REA
DescriptorTyrosine-protein kinase HCK, Protein Nef, single domain antibody sdAb19, ... (4 entities in total)
Functional Keywordssh3 domain, immunglobolin fold, antibodies, epitopes, hiv antibodies, hiv accessory proteins, pxxp motif, complementarity determining regions, transferase-apoptosis-immune system complex, transferase/apoptosis/immune system
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 1: Lysosome. Isoform 2: Cell membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle: P08631
Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407
Total number of polymer chains3
Total formula weight37439.97
Authors
Geyer, M.,Lulf, S. (deposition date: 2014-02-12, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citationLulf, S.,Matz, J.,Rouyez, M.C.,Jarviluoma, A.,Saksela, K.,Benichou, S.,Geyer, M.
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11:24-24, 2014
Cited by
PubMed: 24620746
DOI: 10.1186/1742-4690-11-24
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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