5NUH
Crystal structure of SIVmac239 Nef bound to an engineered Hck SH3 domain
Summary for 5NUH
Entry DOI | 10.2210/pdb5nuh/pdb |
Related | 5NUI |
Descriptor | Protein Nef, Tyrosine-protein kinase HCK,Tyrosine-protein kinase HCK (3 entities in total) |
Functional Keywords | siv, virus, nef, sh3, transferase |
Biological source | Simian immunodeficiency virus (SIV) More |
Cellular location | Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631 |
Total number of polymer chains | 4 |
Total formula weight | 54432.66 |
Authors | Horenkamp, F.A.,Anand, K.,Geyer, M. (deposition date: 2017-04-30, release date: 2017-08-16, Last modification date: 2024-01-17) |
Primary citation | Manrique, S.,Sauter, D.,Horenkamp, F.A.,Lulf, S.,Yu, H.,Hotter, D.,Anand, K.,Kirchhoff, F.,Geyer, M. Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3. Nat Commun, 8:442-442, 2017 Cited by PubMed: 28874665DOI: 10.1038/s41467-017-00481-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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