PDB: 522 resultsInfo pagesStatus searchChemie searchBIRD

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7CSP	Structure of Ephexin4 IDPSH Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSR	Structure of Ephexin4 R676L Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-17 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSO	Structure of Ephexin4 DH-PH-SH3 Descriptor: Rho guanine nucleotide exchange factor 16, SULFATE ION Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7D7S	HIV-1 SF2 Nef in complex with the Fyn SH3 R96I mutant Descriptor: Protein Nef, Tyrosine-protein kinase Fyn Authors: Aldehaiman, A, Shahul Hamed, U.F, Arold, S.T. Deposit date: 2020-10-05 Release date: 2020-11-18 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.32 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
7DPA	Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex Descriptor: Dedicator of cytokinesis protein 5, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 Authors: Kukimoto-Niino, M, Katsura, K, Kaushik, R, Ehara, H, Yokoyama, T, Uchikubo-Kamo, T, Mishima-Tsumagari, C, Yonemochi, M, Ikeda, M, Hanada, K, Zhang, K.Y.J, Shirouzu, M. Deposit date: 2020-12-18 Release date: 2021-08-04 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex. Sci Adv, 7, 2021
8F2P	Nef SF2 dimerization mutant bound to Hck SH3 Descriptor: C-terminal core protein, Tyrosine-protein kinase HCK Authors: Thomas, C.E, Alvarado, J.J, Smithgall, T.E. Deposit date: 2022-11-08 Release date: 2023-02-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.63 Å) Cite: Neutron Reflectometry and Molecular Simulations Demonstrate HIV-1 Nef Homodimer Formation on Model Lipid Bilayers. J.Mol.Biol., 435, 2023
6UY7	Crystal structure of the STAC3 tandem SH3 domains - P269R Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3 Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.105 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
6UY9	Crystal structure of the STAC3 tandem SH3 domains - P269R, W284S Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3, SODIUM ION Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
6UY8	Crystal structure of the STAC3 tandem SH3 domains - P269R, K329N Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SH3 and cysteine-rich domain-containing protein 3 Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.649 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
3JV3	Structure of SH3E-DH unit of murine intersectin-1L Descriptor: Intersectin-1 Authors: Ahmad, K.F. Deposit date: 2009-09-15 Release date: 2010-07-14 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. Plos One, 5, 2010
5YPR	Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor Descriptor: Disks large homolog 4, Synthesized GK inhibitor Authors: Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhu, R, Zhang, M. Deposit date: 2017-11-02 Release date: 2018-03-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.349 Å) Cite: Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs. Cell Rep, 21, 2017
3NMZ	Crystal structure of APC complexed with Asef Descriptor: APC variant protein, Rho guanine nucleotide exchange factor 4 Authors: Zhang, Z, Chen, L, Gao, L, Lin, K, Wu, G. Deposit date: 2010-06-23 Release date: 2011-07-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.01 Å) Cite: Structural basis for the recognition of Asef by adenomatous polyposis coli. Cell Res., 22, 2012
6B25	Crystal structure of human STAC1 Tandem SH3 Domains (288-402) Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SH3 and cysteine-rich domain-containing protein Authors: Wong King Yuen, S.M, Van Petegem, F. Deposit date: 2017-09-19 Release date: 2017-10-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4A63	Crystal structure of the p73-ASPP2 complex at 2.6A resolution Descriptor: ACETATE ION, APOPTOSIS STIMULATING OF P53 PROTEIN 2, TUMOUR PROTEIN 73, ... Authors: Canning, P, Sharpe, T, Krojer, T, Savitsky, P, Cooper, C.D.O, Salah, E, Keates, T, Muniz, J, Vollmar, M, von Delft, F, Weigelt, J, Arrowsmith, C, Bountra, C, Edwards, A, Bullock, A.N. Deposit date: 2011-10-31 Release date: 2011-12-21 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73. J.Mol.Biol., 423, 2012
3REB	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3RBB	HIV-1 NEF protein in complex with engineered HCK SH3 domain Descriptor: 1,2-ETHANEDIOL, Protein Nef, Tyrosine-protein kinase HCK Authors: Horenkamp, F.A, Schulte, A, Weyand, M, Geyer, M. Deposit date: 2011-03-29 Release date: 2011-04-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Conformation of the Dileucine-Based Sorting Motif in HIV-1 Nef Revealed by Intermolecular Domain Assembly. Traffic, 12, 2011
3REA	HIV-1 Nef protein in complex with engineered Hck-SH3 domain Descriptor: Protein Nef, Tyrosine-protein kinase HCK Authors: Schulte, A, Blankenfeldt, W, Geyer, M. Deposit date: 2011-04-04 Release date: 2011-06-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef. PLoS ONE, 6, 2011
3UAT	Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules Descriptor: Disks large homolog 1, phosphor-LGN peptide Authors: Shang, Y, Zhu, J, Wen, W, Zhang, M. Deposit date: 2011-10-22 Release date: 2011-12-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules Embo J., 2011
3TVT	Structural basis for Discs Large interaction with Pins Descriptor: Disks large 1 tumor suppressor protein, Partner of Inscuteable Authors: Johnston, C.A, Doe, C.Q, Prehoda, K.E. Deposit date: 2011-09-20 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural basis for Discs Large interaction with Pins To be Published
7SJ4	Human Trio residues 1284-1959 in complex with Rac1 Descriptor: Ras-related C3 botulinum toxin substrate 1, Triple functional domain protein Authors: Chen, C.-L, Ravala, S.K, Bandekar, S.J, Cash, J, Tesmer, J.J.G. Deposit date: 2021-10-15 Release date: 2022-07-06 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298, 2022
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Descriptor: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn Authors: Arold, S.T, Hoh, F, Dumas, C. Deposit date: 2012-01-10 Release date: 2013-01-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5201 Å) Cite: Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
3EHQ	Crystal Structure of Human Osteoclast Stimulating Factor Descriptor: 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1 Authors: Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. Deposit date: 2008-09-14 Release date: 2009-08-04 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
3EHR	Crystal Structure of Human Osteoclast Stimulating Factor Descriptor: Osteoclast-stimulating factor 1 Authors: Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. Deposit date: 2008-09-14 Release date: 2009-08-04 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
5FUL	Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with SAH Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... Authors: Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. Deposit date: 2016-01-27 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017
5FWA	Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP1 Descriptor: 1,2-ETHANEDIOL, 9-(6-carbamimidamido-5,6-dideoxy-beta-D-ribo-hexofuranosyl)-9H-purin-6-amine, CALCIUM ION, ... Authors: Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. Deposit date: 2016-02-16 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017

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