4D8D

Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant

Summary for 4D8D

• Entry DOI: 10.2210/pdb4d8d/pdb
• Related: 3H0F 3H0H 3H0I
• Descriptor: Tyrosine-protein kinase Fyn, Protein Nef, GLYCEROL, ... (4 entities in total)
• Functional Keywords: signaling molecules, transferase-protein binding complex, transferase/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P06241; Host cell membrane ; Lipid-anchor ; Cytoplasmic side : P03406
• Total number of polymer chains: 4
• Total formula weight: 48533.96

Authors

Arold, S.T.,Hoh, F.,Dumas, C. (deposition date: 2012-01-10, release date: 2013-01-16, Last modification date: 2023-09-13)

• Primary citation: Aldehaiman, A.,Momin, A.A.,Restouin, A.,Wang, L.,Shi, X.,Aljedani, S.,Opi, S.,Lugari, A.,Shahul Hameed, U.F.,Ponchon, L.,Morelli, X.,Huang, M.,Dumas, C.,Collette, Y.,Arold, S.T.; Synergy and allostery in ligand binding by HIV-1 Nef.; Biochem.J., 478:1525-1545, 2021; PubMed: 33787846; DOI: 10.1042/BCJ20201002

Experimental method

X-RAY DIFFRACTION (2.5201 Å)