PDB: 278 resultsInfo pagesStatus searchChemie searchBIRD

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4GNI	Structure of the Ssz1 ATPase bound to ATP and Magnesium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein Authors: Bange, G, Sinning, I. Deposit date: 2012-08-17 Release date: 2012-12-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.796 Å) Cite: Structural characterization of a eukaryotic chaperone-the ribosome-associated complex. Nat.Struct.Mol.Biol., 20, 2013
4H5V	HSC70 NBD with Mg Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ... Authors: Stec, B. Deposit date: 2012-09-18 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4EZS	Crystal structure of the substrate binding domain of E.coli DnaK in complex with metchnikowin (residues 20 to 26) Descriptor: Chaperone protein DnaK, Metchnikowin, SULFATE ION Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-24 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural studies of DnaK in complex with proline rich antimicrobial peptides reveal two different peptide binding modes To be Published
4EZY	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLILTG Descriptor: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLILTG Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZN	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin Descriptor: Chaperone protein DnaK, Pyrrhocoricin Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4EZX	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the designer peptide NRLMLTG Descriptor: Chaperone protein DnaK, SULFATE ION, synthetic peptide NRLMLTG Authors: Zahn, M, Straeter, N. Deposit date: 2012-05-03 Release date: 2013-04-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4H5W	HSC70 NBD with betaine Descriptor: ACETATE ION, Heat shock cognate 71 kDa protein, MAGNESIUM ION, ... Authors: Stec, B. Deposit date: 2012-09-19 Release date: 2014-03-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.94 Å) Cite: New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4HY9	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZZ (residues 1 to 11) Descriptor: Chaperone protein DnaK, Pyrrhocoricin, SULFATE ION Authors: Zahn, M, Straeter, N. Deposit date: 2012-11-13 Release date: 2013-04-17 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
4FL9	Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Heat shock cognate 71 kDa protein, trimethylamine oxide Authors: Grimm, C. Deposit date: 2012-06-14 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Crystal Structure of bovine hsc70(aa1-554)E213A/D214A at 1.9A Resolution TO BE PUBLISHED
4H5T	HSC70 NBD with ADP and Mg Descriptor: ADENOSINE-5'-DIPHOSPHATE, Heat shock cognate 71 kDa protein, MAGNESIUM ION, ... Authors: Stec, B. Deposit date: 2012-09-18 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4H5N	HSC70 NBD with PO4, Na, Cl Descriptor: CHLORIDE ION, GLYCEROL, Heat shock cognate 71 kDa protein, ... Authors: Stec, B. Deposit date: 2012-09-18 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.86 Å) Cite: New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4H5R	HSC70 NBD with Na, Cl and glycerol Descriptor: CHLORIDE ION, GLYCEROL, Heat shock cognate 71 kDa protein, ... Authors: Stec, B. Deposit date: 2012-09-18 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.64 Å) Cite: New crystal structures of HSC-70 ATP binding domain confirm the role of individual binding pockets and suggest a new method of inhibition. Biochimie, 108, 2015
4HYB	Crystal structure of the substrate binding domain of E.coli DnaK in complex with pyrrhocoricin_LYZI (residues 1 to 10) Descriptor: Chaperone protein DnaK, Pyrrhocoricin, SULFATE ION Authors: Zahn, M, Straeter, N. Deposit date: 2012-11-13 Release date: 2013-04-17 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J.Mol.Biol., 425, 2013
5AQX	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues Descriptor: (1R,2S,3R,5R)-3-((5-(benzyloxy)quinazolin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. Deposit date: 2015-09-22 Release date: 2016-10-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.12 Å) Cite: A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AR0	HSP72 with adenosine-derived inhibitor Descriptor: (2R,3R,4S,5R)-2-(6-amino-8-((quinolin-7-ylmethyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Cheeseman, M.D, Westwood, I.M, Barbeau, O, Rowlands, M.G, Jones, A.M, Jeganathan, F, Burke, R, Dobson, S.E, Workman, P, Collins, I, van Montfort, R.L.M, Jones, K. Deposit date: 2015-09-22 Release date: 2016-05-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70. J.Med.Chem., 59, 2016
5BPL	Crystal structure of ADP and Pi bound human Hsp70 NBD mutant R272K. Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Narayanan, D, Engh, R.A. Deposit date: 2015-05-28 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BPN	Crystal structure of nucleotide-free human Hsp70 NBD double mutant E268Q+R272K. Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... Authors: Narayanan, D, Engh, R.A. Deposit date: 2015-05-28 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BN8	Crystal structure of nucleotide-free human Hsp70 NBD. Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... Authors: Narayanan, D, Engh, R.A. Deposit date: 2015-05-25 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BPM	Crystal structure of unhydrolyzed ATP bound human Hsp70 NBD double mutant E268Q+R272K. Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A, ... Authors: Narayanan, D, Engh, R.A. Deposit date: 2015-05-28 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Nucleotide binding to variants of the HSP70-NBD. To Be Published
5BN9	Crystal structure of ADP bound human Hsp70 NBD mutant R272K. Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Narayanan, D, Engh, R.A. Deposit date: 2015-05-25 Release date: 2016-09-14 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.689 Å) Cite: Nucleotide binding to variants of the HSP70-NBD. To Be Published
5AQZ	HSP72 with adenosine-derived inhibitor Descriptor: 1,2-ETHANEDIOL, HEAT SHOCK 70 KDA PROTEIN 1A, SANGIVAMYCIN Authors: Cheeseman, M.D, Westwood, I.M, Barbeau, O, Rowlands, M.G, Jones, A.M, Jeganathan, F, Burke, R, Dobson, S.E, Workman, P, Collins, I, van Montfort, R.L.M, Jones, K. Deposit date: 2015-09-22 Release date: 2016-05-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of Hsp70. J.Med.Chem., 59, 2016
5AQW	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues Descriptor: (1S,2R,3R,5R)-3-(hydroxymethyl)-5-(quinazolin-4-ylamino)cyclopentane-1,2-diol, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2-ETHANEDIOL, ... Authors: Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. Deposit date: 2015-09-22 Release date: 2016-10-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.53 Å) Cite: A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
5AQY	Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues Descriptor: 1,2-ETHANEDIOL, ADENOSINE, DIMETHYL SULFOXIDE, ... Authors: Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. Deposit date: 2015-09-22 Release date: 2016-10-05 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.56 Å) Cite: A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016
7OLC	Thermophilic eukaryotic 80S ribosome at idle POST state Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... Authors: Kisonaite, M, Wild, K, Sinning, I. Deposit date: 2021-05-19 Release date: 2022-01-26 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
4E81	Crystal structure of the substrate binding domain of E.coli DnaK in complex with a short apidaecin peptide Descriptor: Chaperone protein DnaK, SULFATE ION, apidaecin peptide fragment Authors: Zahn, M, Straeter, N. Deposit date: 2012-03-19 Release date: 2012-05-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Api88 is a novel antibacterial designer Peptide to treat systemic infections with multidrug-resistant gram-negative pathogens. Acs Chem.Biol., 7, 2012

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