PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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7Z3N	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
7Z3O	Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation 分子名称: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... 著者 Kisonaite, M, Wild, K, Sinning, I. 登録日 2022-03-02 公開日 2023-04-12 最終更新日 2023-05-31 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural inventory of cotranslational protein folding by the eukaryotic RAC complex. Nat.Struct.Mol.Biol., 30, 2023
8GB3	Structure of the Mycobacterium tuberculosis Hsp70 protein DnaK bound to the nucleotide exchange factor GrpE 分子名称: Chaperone protein DnaK, Protein GrpE 著者 Xiao, X, Li, H. 登録日 2023-02-24 公開日 2024-01-31 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled. Nat Commun, 15, 2024
4ANI	Structural basis for the intermolecular communication between DnaK and GrpE in the DnaK chaperone system from Geobacillus kaustophilus HTA426 分子名称: CHAPERONE PROTEIN DNAK, PROTEIN GRPE 著者 Wu, C.-C, Naveen, V, Chien, C.-H, Chang, Y.-W, Hsiao, C.-D. 登録日 2012-03-19 公開日 2012-05-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (4.094 Å) 主引用文献 Crystal Structure of Dnak Protein Complexed with Nucleotide Exchange Factor Grpe in Dnak Chaperone System: Insight Into Intermolecular Communication. J.Biol.Chem., 287, 2012
7SQC	Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii 分子名称: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... 著者 Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. 登録日 2021-11-05 公開日 2022-04-13 最終更新日 2022-06-08 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat.Struct.Mol.Biol., 29, 2022
3QML	The structural analysis of Sil1-Bip complex reveals the mechanism for Sil1 to function as a novel nucleotide exchange factor 分子名称: 78 kDa glucose-regulated protein homolog, MAGNESIUM ION, Nucleotide exchange factor SIL1, ... 著者 Yan, M, Li, J.Z, Sha, B.D. 登録日 2011-02-04 公開日 2011-06-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
1XQS	Crystal structure of the HspBP1 core domain complexed with the fragment of Hsp70 ATPase domain 分子名称: ADENOSINE MONOPHOSPHATE, HSPBP1 protein, Heat shock 70 kDa protein 1 著者 Shomura, Y, Dragovic, Z, Chang, H.C, Tzvetkov, N, Young, J.C, Brodsky, J.L, Guerriero, V, Hartl, F.U, Bracher, A. 登録日 2004-10-13 公開日 2005-03-01 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Regulation of Hsp70 Function by HspBP1; Structural Analysis Reveals an Alternate Mechanism for Hsp70 Nucleotide Exchange Mol.Cell, 17, 2005
6U42	Natively decorated ciliary doublet microtubule 分子名称: DC1, DC2, DC3, ... 著者 Ma, M, Stoyanova, M, Rademacher, G, Dutcher, S.K, Brown, A, Zhang, R. 登録日 2019-08-22 公開日 2019-11-13 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of the Decorated Ciliary Doublet Microtubule. Cell, 179, 2019
1HX1	CRYSTAL STRUCTURE OF A BAG DOMAIN IN COMPLEX WITH THE HSC70 ATPASE DOMAIN 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG family molecular chaperone regulator 1, Heat shock 70 kDa protein 8 著者 Sondermann, H, Scheufler, C, Moarefi, I. 登録日 2001-01-11 公開日 2001-03-07 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science, 291, 2001
6HA7	Crystal structure of the BiP NBD and MANF complex 分子名称: 1,2-ETHANEDIOL, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor 著者 Yan, Y, Ron, D. 登録日 2018-08-07 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
6H9U	Crystal structure of the BiP NBD and MANF SAP complex 分子名称: D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ... 著者 Yan, Y, Ron, D. 登録日 2018-08-06 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP. Nat Commun, 10, 2019
5NRO	Structure of full-length DnaK with bound J-domain 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaJ, Chaperone protein DnaK, ... 著者 Kopp, J, Kityk, R, Mayer, M.P. 登録日 2017-04-25 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones. Mol. Cell, 69, 2018
7JN9	Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide QEHTGSQLRIAAYGP 分子名称: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION 著者 Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. 登録日 2020-08-04 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
6ZMD	Crystal structure of HYPE covalently tethered to BiP bound to AMP-PNP 分子名称: Endoplasmic reticulum chaperone BiP, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Fauser, J, Gulen, B, Pett, C, Hedberg, C, Itzen, A, Pogenberg, V. 登録日 2020-07-02 公開日 2021-04-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.64 Å) 主引用文献 Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD. Nat Commun, 12, 2021
3LDQ	Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor 分子名称: 8-[(quinolin-2-ylmethyl)amino]adenosine, BAG family molecular chaperone regulator 1, Heat shock cognate 71 kDa protein 著者 Dokurno, P, Surgenor, A.E, Shaw, T, Macias, A.T, Massey, A.J, Williamson, D.S. 登録日 2010-01-13 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. J.Med.Chem., 54, 2011
7B80	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2) 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... 著者 Perera, L.A, Ron, D. 登録日 2020-12-12 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. Nat Commun, 12, 2021
7B7Z	DeAMPylation complex of monomeric FICD and AMPylated BiP (state 1) 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Endoplasmic reticulum chaperone BiP, ... 著者 Perera, L.A, Ron, D. 登録日 2020-12-12 公開日 2021-07-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD. Nat Commun, 12, 2021
3M3Z	Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor 分子名称: 5'-O-(2-amino-2-oxoethyl)-8-(methylamino)adenosine, BAG family molecular chaperone regulator 1, Heat shock cognate 71 kDa protein 著者 Dokurno, P, Surgenor, A.E, Shaw, T, Macias, A.T, Massey, A.J, Williamson, D.S. 登録日 2010-03-10 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity. J.Med.Chem., 54, 2011
3A8Y	Crystal structure of the complex between the BAG5 BD5 and Hsp70 NBD 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG family molecular chaperone regulator 5, Heat shock 70 kDa protein 1 著者 Arakawa, A, Handa, N, Ohsawa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2009-10-13 公開日 2010-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange Structure, 18, 2010
1DKG	CRYSTAL STRUCTURE OF THE NUCLEOTIDE EXCHANGE FACTOR GRPE BOUND TO THE ATPASE DOMAIN OF THE MOLECULAR CHAPERONE DNAK 分子名称: MOLECULAR CHAPERONE DNAK, NUCLEOTIDE EXCHANGE FACTOR GRPE 著者 Harrison, C.J, Kuriyan, J. 登録日 1997-02-13 公開日 1997-08-20 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science, 276, 1997
7KW7	Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR 分子名称: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... 著者 Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. 登録日 2020-11-30 公開日 2021-12-08 最終更新日 2022-02-02 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
3FZK	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 分子名称: (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG family molecular chaperone regulator 1, ... 著者 Dokurno, P, Williamson, D.S, Murray, J.B, Surgenor, A.E. 登録日 2009-01-26 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design J.Med.Chem., 52, 2009
3FZL	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, BAG family molecular chaperone regulator 1, ... 著者 Dokurno, P, Williamson, D.S, Murray, J.B, Surgenor, A.E. 登録日 2009-01-26 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design J.Med.Chem., 52, 2009
3FZM	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 分子名称: 4-[[(2R,3S,4R,5R)-5-[6-amino-8-(quinolin-6-ylmethylamino)purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitri le, BAG family molecular chaperone regulator 1, Heat shock cognate 71 kDa protein 著者 Dokurno, P, Williamson, D.S, Murray, J.B, Surgenor, A.E. 登録日 2009-01-26 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design J.Med.Chem., 52, 2009
3FZH	Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, BAG family molecular chaperone regulator 1, Heat shock cognate 71 kDa protein 著者 Dokurno, P, Williamson, D.S, Murray, J.B, Surgenor, A.E. 登録日 2009-01-26 公開日 2009-03-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design J.Med.Chem., 52, 2009

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