PDB: 114 resultsInfo pagesStatus searchChemie searchBIRD

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5MG2	Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe Descriptor: 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Transcription initiation factor TFIID subunit 1 Authors: Tallant, C, Bouche, L, Holton, S.J, Fedorov, O, Siejka, P, Picaud, S, Krojer, T, Srikannathasan, V, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hartung, I.V, Haendler, B, Muller, S, Huber, K.V.M, Structural Genomics Consortium (SGC) Deposit date: 2016-11-20 Release date: 2017-05-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
5N49	BRPF2 in complex with Compound 7 Descriptor: 2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, Bromodomain-containing protein 1 Authors: Bouche, L, Christ, C.D, Siegel, S, Fernandez-Montalvan, A.E, Holton, S.J, Fedorov, O, ter Laak, A, Sugawara, T, Stoeckigt, D, Tallant, C, Bennett, J, Monteiro, O, Saez, L.D, Siejka, P, Meier, J, Puetter, V, Weiske, J, Mueller, S, Huber, K.V.M, Hartung, I.V, Haendler, B. Deposit date: 2017-02-10 Release date: 2017-05-03 Last modified: 2017-05-24 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60, 2017
7T7T	Structure of TSK/BRU1 bound to histone H3.1 Descriptor: Histone H3.1, Protein TONSOKU Authors: Davarinejad, H, Couture, J.F. Deposit date: 2021-12-15 Release date: 2022-03-30 Method: X-RAY DIFFRACTION (3.17 Å) Cite: The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science, 375, 2022
7EA5	Yeast Set2 bound to a nucleosome containing oncohistone mutations Descriptor: 601-DNA, Histone H2A, Histone H2B, ... Authors: Jing, H, Liu, Y. Deposit date: 2021-03-06 Release date: 2021-07-14 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations. Cell Discov, 7, 2021
5BO0	Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer Descriptor: DNA replication licensing factor MCM2, GLYCEROL, Histone H3.2, ... Authors: Huang, H, Patel, D.J. Deposit date: 2015-05-26 Release date: 2015-06-17 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.906 Å) Cite: A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. Nat.Struct.Mol.Biol., 22, 2015
5DX0	Crystal structure of CARM1, sinefungin, and H3 peptide (R17) Descriptor: GLYCEROL, H3 peptide, Histone-arginine methyltransferase CARM1, ... Authors: Boriack-Sjodin, P.A. Deposit date: 2015-09-23 Release date: 2015-11-25 Last modified: 2016-03-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol., 11, 2016
5DWQ	Crystal structure of CARM1, sinefungin, and methylated H3 peptide (R17) Descriptor: GLYCEROL, Histone-arginine methyltransferase CARM1, SINEFUNGIN, ... Authors: Boriack-Sjodin, P.A. Deposit date: 2015-09-22 Release date: 2015-11-25 Last modified: 2016-03-30 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates. Acs Chem.Biol., 11, 2016
2RI5	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358A point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, TRIETHYLENE GLYCOL Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI2	Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355A point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, SULFATE ION, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHI	Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with H1.5K27me2 at 1.66 angstrom Descriptor: DI(HYDROXYETHYL)ETHER, Histone H1.5, Lethal(3)malignant brain tumor-like protein, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHY	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to monomethyl-lysine Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein, N-METHYL-LYSINE Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHX	Crystal structure of the 3-MBT repeats from human L3MBTL1 bound to dimethyl-lysine Descriptor: Lethal(3)malignant brain tumor-like protein, N-DIMETHYL-LYSINE, SULFATE ION, ... Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RI3	Crystal structure of the 3-MBT repeats from human L3MBTL1 with N358Q point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein Authors: Li, H, Patel, D.J. Deposit date: 2007-10-10 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007
2RHZ	Crystal structure of the 3-MBT repeats from human L3MBTL1 with D355N point mutation Descriptor: DI(HYDROXYETHYL)ETHER, Lethal(3)malignant brain tumor-like protein Authors: Li, H, Patel, D.J. Deposit date: 2007-10-09 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger. Mol.Cell, 28, 2007

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