5MG2

Crystal structure of the second bromodomain of human TAF1 in complex with BAY-299 chemical probe

Summary for 5MG2

Entry DOI	10.2210/pdb5mg2/pdb
Descriptor	Transcription initiation factor TFIID subunit 1, 1,2-ETHANEDIOL, 6-(3-oxidanylpropyl)-2-(1,3,6-trimethyl-2-oxidanylidene-benzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione, ... (4 entities in total)
Functional Keywords	transcription, structural genomics, structural genomics consortium, sgc
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P21675
Total number of polymer chains	1
Total formula weight	16498.48
Authors	Tallant, C.,Bouche, L.,Holton, S.J.,Fedorov, O.,Siejka, P.,Picaud, S.,Krojer, T.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Hartung, I.V.,Haendler, B.,Muller, S.,Huber, K.V.M.,Structural Genomics Consortium (SGC) (deposition date: 2016-11-20, release date: 2017-05-03, Last modification date: 2024-01-17)
Primary citation	Bouche, L.,Christ, C.D.,Siegel, S.,Fernandez-Montalvan, A.E.,Holton, S.J.,Fedorov, O.,Ter Laak, A.,Sugawara, T.,Stockigt, D.,Tallant, C.,Bennett, J.,Monteiro, O.,Diaz-Saez, L.,Siejka, P.,Meier, J.,Putter, V.,Weiske, J.,Muller, S.,Huber, K.V.M.,Hartung, I.V.,Haendler, B. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J. Med. Chem., 60:4002-4022, 2017 Cited by PubMed: 28402630 DOI: 10.1021/acs.jmedchem.7b00306 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation