PDB: 970 件ウェブページステータス検索Chemie searchBIRD

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7B5R	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27 分子名称: Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-07 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 分子名称: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-04 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
2JID	Human Dipeptidyl peptidase IV in complex with 1-(3,4-Dimethoxy-phenyl) -3-m-tolyl-piperidine-4-ylamine 分子名称: (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIPEPTIDYL PEPTIDASE 4 著者 Hennig, M, Stihle, M, Luebbers, T, Thoma, R. 登録日 2007-02-28 公開日 2008-05-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 1,3-Disubstituted 4-Aminopiperidines as Useful Tools in the Optimization of the 2-Aminobenzo[A]Quinolizine Dipeptidyl Peptidase Iv Inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
6DKJ	human GIPR ECD and Fab complex 分子名称: 1,2-ETHANEDIOL, Fab heavy chain, Fab light chain, ... 著者 Min, X, Wang, Z. 登録日 2018-05-29 公開日 2019-05-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models. Sci Transl Med, 10, 2018
7AXW	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1-aminoisoquinoline and PKI (5-24) 分子名称: ISOQUINOLIN-1-AMINE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
7AXV	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 5-isoquinolinesulfonic acid and PKI (5-24) 分子名称: DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
7AXT	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with isoquinoline-5-carboxylic acid and PKI (5-24) 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, isoquinoline-5-carboxylic acid 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
6E21	Joint X-ray/neutron structure of PKAc with products Sr2-ADP and phosphorylated peptide SP20 分子名称: ADENOSINE-5'-DIPHOSPHATE, STRONTIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Kovalevsky, A, Gerlits, O.O, Taylor, S. 登録日 2018-07-10 公開日 2019-04-03 最終更新日 2023-10-25 実験手法 NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION 主引用文献 Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex. Sci Adv, 5, 2019
6E3Y	Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor 分子名称: Calcitonin gene-related peptide 1, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Deganutti, G, Glukhova, A, Koole, C, Peat, T.S, Radjainia, M, Plitzko, J.M, Baumeister, W, Miller, L.J, Hay, D.L, Christopoulos, A, Reynolds, C.A, Wootten, D, Sexton, P.M. 登録日 2018-07-16 公開日 2018-09-19 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561, 2018
7BW0	Active human TGR5 complex with a synthetic agonist 23H 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. 登録日 2020-04-12 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020
6EH0	Apo crystal structure of the Protein-Kinase A catalytic subunit from Criteculus 分子名称: cAMP-dependent protein kinase catalytic subunit alpha 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-09-12 公開日 2018-10-10 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
7BZ2	Cryo-EM structure of the formoterol-bound beta2 adrenergic receptor-Gs protein complex. 分子名称: Beta2 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y.N, Yang, F, Ling, S.L, Lv, P, Zhou, Y.X, Fang, W, Sun, W, Shi, P, Tian, C.L. 登録日 2020-04-26 公開日 2020-08-05 実験手法 ELECTRON MICROSCOPY (3.82 Å) 主引用文献 Single-particle cryo-EM structural studies of the beta2AR-Gs complex bound with a full agonist formoterol. Cell Discov, 6, 2020
6ERW	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 and Fasudil 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-19 公開日 2018-10-31 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6ESA	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and AMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, beta-D-ribopyranose, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-19 公開日 2018-10-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.307 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6EH3	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp190 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor, ~{N}-[2-[(phenylmethyl)amino]ethyl]isoquinoline-5-sulfonamide 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-09-12 公開日 2018-10-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp190 To be published
6EH2	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp032 and AMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-09-12 公開日 2018-10-10 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6E87	Crystal structure of ferrous form of the crosslinked human cysteine dioxygenase in the anaerobic condition 分子名称: Cysteine dioxygenase type 1, FE (II) ION, GLYCEROL, ... 著者 Liu, A, Li, J. 登録日 2018-07-27 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.952 Å) 主引用文献 Probing the Cys-Tyr Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine. Biochemistry, 58, 2019
6EGW	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp017 and RKp117 分子名称: [2-[(4-isoquinolin-5-ylsulfonyl-1,4-diazepan-1-yl)methyl]phenyl]boronic acid, alpha-D-ribofuranose, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-09-12 公開日 2018-10-10 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6ERU	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compound RKp120 分子名称: UPF0418 protein FAM164A, cAMP-dependent protein kinase catalytic subunit alpha 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-19 公開日 2018-10-31 最終更新日 2020-07-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6EM7	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and ADP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, UPF0418 protein FAM164A, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-01 公開日 2018-10-10 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.238 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
7BPH	Crystal structure of GppNHp-bound GNAS in complex with the cyclic peptide inhibitor GN13 分子名称: CHLORIDE ION, GLYCEROL, GN13, ... 著者 Hu, Q, Dai, S, Shokat, K.M. 登録日 2020-03-22 公開日 2021-03-31 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 2022
6EG8	Structure of the GDP-bound Gs heterotrimer 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Hilger, D, Liu, X, Aschauer, P, Kobilka, B.K. 登録日 2018-08-19 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Process of GPCR-G Protein Complex Formation. Cell, 177, 2019
6EM2	Crystal structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with Fasudil 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, cAMP-dependent protein kinase catalytic subunit alpha 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-01 公開日 2018-10-10 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6EMA	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, beta-D-ribopyranose, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-01 公開日 2018-10-10 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
6ERV	Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp013 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor 著者 Mueller, J.M, Heine, A, Klebe, G. 登録日 2017-10-19 公開日 2018-10-31 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019

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