PDB: 847 resultsInfo pagesStatus searchChemie searchBIRD

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7UJ1	Crystal structure of PSF-RNA complex Descriptor: RNA (30-MER), Splicing factor, proline- and glutamine-rich Authors: Sachpatzidis, A, Wang, J, Konigsberg, W.H. Deposit date: 2022-03-30 Release date: 2022-09-28 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1. Biochemistry, 61, 2022
7U0H	State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model Descriptor: 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ... Authors: Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. Deposit date: 2022-02-18 Release date: 2022-12-14 Last modified: 2022-12-28 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
7SP0	Crystal structure of human SFPQ L534I mutant in complex with zinc Descriptor: Splicing factor, proline- and glutamine-rich, ZINC ION Authors: Lee, M. Deposit date: 2021-11-01 Release date: 2022-10-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. Open Biology, 12, 2022
7SN6	U2AF65 UHM BOUND TO SF3B155 ULM5 Descriptor: ISOPROPYL ALCOHOL, Splicing factor 3B subunit 1, Splicing factor U2AF 65 kDa subunit Authors: Loerch, S, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2021-10-27 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing. J.Biol.Chem., 298, 2022
7SLQ	Cryo-EM structure of 7SK core RNP with circular RNA Descriptor: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Minimal circular 7SK RNA, ... Authors: Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. Deposit date: 2021-10-24 Release date: 2022-03-30 Last modified: 2022-05-18 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
7SLP	Cryo-EM structure of 7SK core RNP with linear RNA Descriptor: 7SK snRNA methylphosphate capping enzyme, La-related protein 7, Linear 7SK RNA, ... Authors: Yang, Y, Liu, S, Zhou, Z.H, Feigon, J. Deposit date: 2021-10-24 Release date: 2022-03-30 Last modified: 2022-05-18 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. Mol.Cell, 82, 2022
7S7C	Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2) Descriptor: Exosome RNA helicase MTR4, RNA (30-MER), RNA-binding protein 7, ... Authors: Puno, M.R, Lima, C.D. Deposit date: 2021-09-15 Release date: 2022-06-15 Last modified: 2022-06-22 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex. Cell, 185, 2022
7S7B	Human Nuclear exosome targeting (NEXT) complex homodimer bound to RNA (substrate 1) Descriptor: Exosome RNA helicase MTR4, RNA (46-MER), RNA-binding protein 7, ... Authors: Puno, M.R, Lima, C.D. Deposit date: 2021-09-15 Release date: 2022-06-15 Last modified: 2022-06-22 Method: ELECTRON MICROSCOPY (4.06 Å) Cite: Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex. Cell, 185, 2022
7S3C	Crystal structure of intact U2AF65 RRM-region bound to AdML-A5 oligonucleotide Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*AP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Glasser, E, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
7S3B	Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide Descriptor: DI(HYDROXYETHYL)ETHER, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Jenkins, J.L, Henderson, S, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2022-06-29 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
7S3A	Crystal structure of intact U2AF65 RRM-region bound to AdML-C5 oligonucleotide Descriptor: DNA/RNA (5'-R(P*UP*UP*(UD)P*CP*U)-D(P*(BRU))-R(P*CP*C)-3'), SODIUM ION, Splicing factor U2AF 65 kDa subunit Authors: Jenkins, J.L, Henderson, S, Kielkopf, C.L. Deposit date: 2021-09-05 Release date: 2022-05-25 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal. Nucleic Acids Res., 50, 2022
7R7A	State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ... Authors: Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. Deposit date: 2021-06-24 Release date: 2022-11-09 Last modified: 2022-12-28 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
7R6Q	State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ... Authors: Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P. Deposit date: 2021-06-23 Release date: 2022-11-09 Last modified: 2022-12-28 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Sequence-specific remodeling of a topologically complex RNP substrate by Spb4. Nat.Struct.Mol.Biol., 29, 2022
7QZP	Identification and characterization of an RRM-containing, ELAV-like, RNA binding protein in Acinetobacter Baumannii Descriptor: Hypothetical RNA binding protein from Acinetobacter baumannii Authors: Ciani, C, Perez-Rafols, A, Bonomo, I, Micaelli, M, Esposito, A, Zucal, C, Belli, R, D'Agostino, V.G, Bianconi, I, Calderone, V, Cerofolini, L, Fragai, M, Provenzani, A. Deposit date: 2022-01-31 Release date: 2022-07-13 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Identification and Characterization of an RRM-Containing, RNA Binding Protein in Acinetobacter baumannii . Biomolecules, 12, 2022
7QTT	Structural organization of a late activated human spliceosome (Baqr, core region) Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... Authors: Cretu, C, Pena, V. Deposit date: 2022-01-15 Release date: 2023-05-10 Last modified: 2023-06-14 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of catalytic activation in human splicing. Nature, 617, 2023
7QR4	human CPEB3 HDV-like ribozyme Descriptor: RNA CPEB3 ribozyme, U1 small nuclear ribonucleoprotein A Authors: Przytula-Mally, A.I, Engilberge, S, Johannsen, S, Olieric, V, Masquida, B, Sigel, R.K.O. Deposit date: 2022-01-17 Release date: 2022-10-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.83 Å) Cite: Anticodon-like loop-mediated dimerization in the crystal structures of HdV-like CPEB3 ribozymes Biorxiv, 2022
7QR3	Chimpanzee CPEB3 HDV-like ribozyme Descriptor: GLYCEROL, POTASSIUM ION, U1 small nuclear ribonucleoprotein A, ... Authors: Przytula-Mally, A.I, Engilberge, S, Johannsen, S, Olieric, V, Masquida, B, Sigel, R.K.O. Deposit date: 2022-01-10 Release date: 2022-10-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Anticodon-like loop-mediated dimerization in the crystal structures of HdV-like CPEB3 ribozymes Biorxiv, 2022
7QP7	Structure of the human 48S initiation complex in closed state (h48S AUG closed) Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. Deposit date: 2022-01-03 Release date: 2022-05-11 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
7QP6	Structure of the human 48S initiation complex in open state (h48S AUG open) Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... Authors: Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. Deposit date: 2022-01-03 Release date: 2022-05-11 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
7QDE	NMR structure of Npl3 RRM12 bound to the AUCCAGUGGAA RNA Descriptor: Nucleolar protein 3, RNA (5'-R(*AP*UP*CP*CP*AP*GP*UP*GP*GP*AP*A)-3') Authors: Allain, F.H.-T, Clery, A, Moursy, A. Deposit date: 2021-11-26 Release date: 2022-12-21 Last modified: 2024-01-10 Method: SOLUTION NMR Cite: RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing. Nat Commun, 14, 2023
7QDD	NMR structure of Npl3 RRM1 bound to the AUCCAA RNA Descriptor: Nucleolar protein 3, RNA (5'-R(*AP*UP*CP*CP*AP*A)-3') Authors: Clery, A, Allain, F.H.-T, Moursy, A. Deposit date: 2021-11-26 Release date: 2022-10-26 Last modified: 2024-01-10 Method: SOLUTION NMR Cite: RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing. Nat Commun, 14, 2023
7Q8A	Crystal structure of tandem domain RRM1-2 of FUBP-interacting repressor (FIR) bound to FUSE ssDNA fragment Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(P*GP*T)-3'), Poly(U)-binding-splicing factor PUF60, ... Authors: Ni, X, Joerger, A.C, Chaikuad, A, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2021-11-10 Release date: 2022-11-09 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal structure of tandem domain RRM1-2 of FIR bound to FUSE ssDNA fragment To Be Published
7Q4O	Substrate-bound A-like U2 snRNP Descriptor: BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ... Authors: Tholen, J, Galej, W.P. Deposit date: 2021-11-01 Release date: 2022-03-30 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022
7Q4L	The solution structure of hsDND1 RRM12 bound to CUUAUUUG RNA Descriptor: Dead end protein homolog 1, RNA (5'-R(*CP*UP*UP*AP*UP*UP*UP*G)-3') Authors: Duszczyk, M.M, Allain, F.H.T. Deposit date: 2021-10-31 Release date: 2022-05-04 Last modified: 2022-10-19 Method: SOLUTION NMR Cite: The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation. Nat Commun, 13, 2022
7Q3L	Human 17S U2 snRNP 5' domain Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... Authors: Tholen, J, Galej, W.P. Deposit date: 2021-10-28 Release date: 2022-03-30 Method: ELECTRON MICROSCOPY (2.3 Å) Cite: Structural basis of branch site recognition by the human spliceosome. Science, 375, 2022

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