7S3B

Crystal structure of intact U2AF65 RRM-region bound to AdML-G5 oligonucleotide

Summary for 7S3B

• Entry DOI: 10.2210/pdb7s3b/pdb
• Descriptor: Splicing factor U2AF 65 kDa subunit, DNA/RNA (5'-R(P*UP*UP*(UD)P*GP*U)-D(P*(BRU))-R(P*CP*C)-3'), DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: rna splicing factor, rna recognition motif, polypyrimidine tract, rna binding protein-rna-dna complex, rna binding protein/rna/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 24937.91

Authors

Jenkins, J.L.,Henderson, S.,Kielkopf, C.L. (deposition date: 2021-09-05, release date: 2022-05-25, Last modification date: 2022-06-29)

• Primary citation: Glasser, E.,Maji, D.,Biancon, G.,Puthenpeedikakkal, A.M.K.,Cavender, C.E.,Tebaldi, T.,Jenkins, J.L.,Mathews, D.H.,Halene, S.,Kielkopf, C.L.; Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal.; Nucleic Acids Res., 50:5299-5312, 2022; PubMed: 35524551; DOI: 10.1093/nar/gkac287

Experimental method

X-RAY DIFFRACTION (1.89 Å)