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5VJ6
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BG505 SOSIP.664 in complex with broadly neutralizing antibodies PG9 and 8ANC195
Descriptor: 8ANC195 Fab heavy chain, 8ANC195 Fab light chain, Envelope glycoprotein gp160, ...
Authors:Wang, H, Bjorkman, P.J.
Deposit date:2017-04-18
Release date:2017-06-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.
Elife, 6, 2017
5V7J
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Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 35O22 Fab heavy chain, ...
Authors:Stewart-Jones, G.B.E, Zhou, T, Kwong, P.D.
Deposit date:2017-03-20
Release date:2017-06-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
Cell Rep, 19, 2017
5UM8
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Crystal structure of HIV-1 envelope trimer 16055 NFL TD CC (T569G) in complex with Fabs 35022 and PGT124
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 35022 heavy chain, ...
Authors:Garces, F, Stanfield, R.L, Wilson, I.A.
Deposit date:2017-01-26
Release date:2017-05-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.935 Å)
Cite:Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein.
Immunity, 46, 2017
3JCB
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BU of 3jcb by Molmil
Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5
Descriptor: Antibody 36D5 heavy chain, Antibody 36D5 light chain, Envelope glycoprotein gp120, ...
Authors:Hu, G, Liu, J, Roux, K, Taylor, K.A.
Deposit date:2015-11-25
Release date:2017-05-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY
Cite:Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
J. Virol., 91, 2017
3JCC
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Structure of Simian Immunodeficiency Virus Envelope Spikes bound with CD4 and Monoclonal Antibody 36D5
Descriptor: Antibody 36D5 heavy chain, Antibody 36D5 light chain, Envelope glycoprotein gp120, ...
Authors:Hu, G, Liu, J, Roux, K, Taylor, K.A.
Deposit date:2015-11-25
Release date:2017-05-10
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY
Cite:Structure of Simian Immunodeficiency Virus Envelope Spikes Bound with CD4 and Monoclonal Antibody 36D5.
J. Virol., 91, 2017
5V8L
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BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody, ...
Authors:Lee, J.H, Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5V8M
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BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibody 3BNC117
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lee, J.H, Cottrell, C.A, Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5UTY
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BU of 5uty by Molmil
Crystal Structure of a Stabilized DS-SOSIP.mut4 BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, N300M, N302M, T320L in Complex with Human Antibodies PGT122 and 35O22 at 4.1 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Fab heavy chain, ...
Authors:Xu, K, Chuang, G.-Y, Pancera, M, Kwong, P.D.
Deposit date:2017-02-15
Release date:2017-03-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.412 Å)
Cite:Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
J. Virol., 91, 2017
5UTF
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BU of 5utf by Molmil
Crystal Structure of a Stabilized DS-SOSIP.6mut BG505 gp140 HIV-1 Env Trimer, Containing Mutations I201C-P433C (DS), L154M, Y177W, N300M, N302M, T320L, I420M in Complex with Human Antibodies PGT122 and 35O22 at 4.3 A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Heavy chain, ...
Authors:Pancera, M, Chuang, G.-Y, Xu, K, Kwong, P.D.
Deposit date:2017-02-14
Release date:2017-03-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
J. Virol., 91, 2017
5U6E
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BU of 5u6e by Molmil
Crystal structure of clade A/E HIV-1 gp120 core in complex with NBD-14010
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-{(1S)-2-amino-1-[5-(hydroxymethyl)-4-methyl-1,3-thiazol-2-yl]ethyl}-5-(4-chloro-3-fluorophenyl)-1H-pyrrole-2-carboxamide, ...
Authors:Kwon, Y.D, Debnath, A.K, Kwong, P.D.
Deposit date:2016-12-07
Release date:2017-03-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.
J. Med. Chem., 60, 2017
5U1F
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BU of 5u1f by Molmil
Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with CD4 and antibody PGT145
Descriptor: BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ...
Authors:Acharya, P, Kwong, P.D, Potter, C.S, Carragher, B.
Deposit date:2016-11-28
Release date:2017-02-22
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer.
Nat. Struct. Mol. Biol., 24, 2017
5TE4
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BU of 5te4 by Molmil
Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2016-09-20
Release date:2016-11-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
5THR
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BU of 5thr by Molmil
Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex
Descriptor: 17b Fab VH domain, 17b Fab VL domain, 8ANC195 G52K5 VH domain, ...
Authors:Wang, H, Bjorkman, P.J.
Deposit date:2016-09-30
Release date:2016-11-16
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.
Proc.Natl.Acad.Sci.USA, 113, 2016
5TE6
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Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade AE Strain 93TH057 gp120 Core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heavy chain of N6, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2016-09-20
Release date:2016-11-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
5TE7
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BU of 5te7 by Molmil
Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade C Strain DU172.17 gp120 Core
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Zhou, T, Kwong, P.D.
Deposit date:2016-09-20
Release date:2016-11-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
5T3Z
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3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074
Descriptor: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gristick, H.B, Bjorkman, P.J.
Deposit date:2016-08-26
Release date:2016-10-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.
Nat.Struct.Mol.Biol., 23, 2016
5T3X
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3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074.
Descriptor: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gristick, H.B, Bjorkman, P.J.
Deposit date:2016-08-26
Release date:2016-10-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.
Nat.Struct.Mol.Biol., 23, 2016
5T3S
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HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Stanfield, R.L, Wilson, I.A.
Deposit date:2016-08-26
Release date:2016-09-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies.
Immunity, 45, 2016
5D9Q
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BU of 5d9q by Molmil
Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:Julien, J.-P, Stanfield, R.L, Ward, A.B, Wilson, I.A.
Deposit date:2015-08-18
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Plos Pathog., 12, 2016
5KJR
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Crystal structure of the ADCC-potent antibody N60-i3 Fab in complex with HIV-1 Clade A/E gp120 W69A/S115W mutant and M48U1.
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, ...
Authors:Tolbert, W.D, Pazgier, M.
Deposit date:2016-06-20
Release date:2016-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
J.Virol., 90, 2016
5JS9
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Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kong, L, Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kong, L, Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5I8H
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BU of 5i8h by Molmil
Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.664 gp120, ...
Authors:Xu, K, Zhou, T, Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
5I9Q
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BU of 5i9q by Molmil
Crystal structure of 3BNC55 Fab in complex with 426c.TM4deltaV1-3 gp120
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC55 Fab heavy chain, ...
Authors:Scharf, L, Chen, C, Bjorkman, P.J.
Deposit date:2016-02-20
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for germline antibody recognition of HIV-1 immunogens.
Elife, 5, 2016
5FEC
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Crystal structure of 3BNC60 Fab germline precursor in complex with 426c.TM4deltaV1-3 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 426c.TM4deltaV1-3 gp120, ...
Authors:Scharf, L, Bjorkman, P.J.
Deposit date:2015-12-16
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Structural basis for germline antibody recognition of HIV-1 immunogens.
Elife, 5, 2016

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