5D9Q

Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46

Summary for 5D9Q

• Entry DOI: 10.2210/pdb5d9q/pdb
• Related: 4NCO 4TVP 5KZC
• Descriptor: Envelope glycoprotein gp120, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: hiv env glycoprotein; broadly neutralizing antibodies; immune system, immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 15
• Total formula weight: 473368.32

Authors

Julien, J.-P.,Stanfield, R.L.,Ward, A.B.,Wilson, I.A. (deposition date: 2015-08-18, release date: 2016-08-17, Last modification date: 2023-09-27)

• Primary citation: Jardine, J.G.,Sok, D.,Julien, J.P.,Briney, B.,Sarkar, A.,Liang, C.H.,Scherer, E.A.,Henry Dunand, C.J.,Adachi, Y.,Diwanji, D.,Hsueh, J.,Jones, M.,Kalyuzhniy, O.,Kubitz, M.,Spencer, S.,Pauthner, M.,Saye-Francisco, K.L.,Sesterhenn, F.,Wilson, P.C.,Galloway, D.M.,Stanfield, R.L.,Wilson, I.A.,Burton, D.R.,Schief, W.R.; Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.; Plos Pathog., 12:e1005815-e1005815, 2016; PubMed: 27560183; DOI: 10.1371/journal.ppat.1005815

Experimental method

X-RAY DIFFRACTION (4.4 Å)