5U1F
Initial contact of HIV-1 Env with CD4: Cryo-EM structure of BG505 DS-SOSIP trimer in complex with CD4 and antibody PGT145
Summary for 5U1F
Entry DOI | 10.2210/pdb5u1f/pdb |
EMDB information | 8427 |
Descriptor | BG505 DS-SOSIP gp120, BG505 SOSIP gp41, PGT145 heavy chain, ... (5 entities in total) |
Functional Keywords | hiv-1 entry early intermediate, cd4 binding site, viral protein-immune system complex, viral protein/immune system |
Biological source | Human immunodeficiency virus 1 (HIV-1) More |
Total number of polymer chains | 9 |
Total formula weight | 323692.03 |
Authors | Acharya, P.,Kwong, P.D.,Potter, C.S.,Carragher, B. (deposition date: 2016-11-28, release date: 2017-02-22, Last modification date: 2018-10-03) |
Primary citation | Liu, Q.,Acharya, P.,Dolan, M.A.,Zhang, P.,Guzzo, C.,Lu, J.,Kwon, A.,Gururani, D.,Miao, H.,Bylund, T.,Chuang, G.Y.,Druz, A.,Zhou, T.,Rice, W.J.,Wigge, C.,Carragher, B.,Potter, C.S.,Kwong, P.D.,Lusso, P. Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer. Nat. Struct. Mol. Biol., 24:370-378, 2017 Cited by PubMed: 28218750DOI: 10.1038/nsmb.3382 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.8 Å) |
Structure validation
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