PDB: 367 resultsInfo pagesStatus searchChemie searchBIRD

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8HI6	Crystal structure of the NADP+ and MSA bound N terminal domain of bi-functional malonyl-CoA reductase from Roseiflexus castenholzii Descriptor: 3-oxidanylidenepropanoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Zhang, X, Wu, W.P, Xu, X. Deposit date: 2022-11-18 Release date: 2023-05-31 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium Roseiflexus castenholzii. Mbio, 14, 2023
8I70	Crystal structure of NADP-binding form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Kim, S, Kim, K.-J. Deposit date: 2023-01-30 Release date: 2023-06-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
8I6Z	Crystal structure of apo-form of malonyl-CoA reductase C-domain from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Kim, S, Kim, K.-J. Deposit date: 2023-01-30 Release date: 2023-06-14 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
8HJW	Bi-functional malonyl-CoA reductuase from Chloroflexus aurantiacus Descriptor: Short-chain dehydrogenase/reductase SDR Authors: Ahn, J.W, Kim, S. Deposit date: 2022-11-24 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Cryo-EM structure of bifunctional malonyl-CoA reductase from Chloroflexus aurantiacus reveals a dynamic domain movement for high enzymatic activity. Int.J.Biol.Macromol., 242, 2023
4BB5	Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors Descriptor: 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Goldberg, F.W, Leach, A.G, Scott, J.S, Snelson, W.L, Groombridge, S.D, Donald, C.S, Bennett, S.N.L, Bodin, C, Morentin Gutierrez, P, Gyte, A.C. Deposit date: 2012-09-20 Release date: 2012-11-28 Last modified: 2012-12-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55, 2012
4BB6	Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors Descriptor: 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... Authors: Goldberg, F.W, Leach, A.G, Scott, J.S, Snelson, W.L, Groombridge, S.D, Donald, C.S, Bennett, S.N.L, Bodin, C, Morentin Gutierrez, P, Gyte, A.C. Deposit date: 2012-09-20 Release date: 2012-11-28 Last modified: 2012-12-26 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55, 2012
8JAT	Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans Descriptor: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Zhao, P, Kuang, Z. Deposit date: 2023-05-07 Release date: 2023-06-21 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans. Biochem.Biophys.Res.Commun., 670, 2023
4BMV	Short-chain dehydrogenase from Sphingobium yanoikuyae in complex with NADPH Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SHORT-CHAIN DEHYDROGENASE Authors: Man, H, Kedziora, K, Lavandera-Garcia, I, Gotor-Fernandez, V, Grogan, G. Deposit date: 2013-05-10 Release date: 2014-03-19 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of Alcohol Dehydrogenases from Ralstonia and Sphingobium Spp. Reveal the Molecular Basis for Their Recognition of 'Bulky-Bulky' Ketones Top.Catal., 57, 2014
4DRY	The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from Rhizobium meliloti Descriptor: 3-oxoacyl-[acyl-carrier-protein] reductase, SULFATE ION Authors: Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) Deposit date: 2012-02-17 Release date: 2012-02-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from Rhizobium meliloti To be Published
4IJW	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine Descriptor: 3-[1-(4-chlorophenyl)cyclopropyl]-8-cyclopropyl[1,2,4]triazolo[4,3-a]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
4IJU	Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with (1S,4S)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol Descriptor: (1s,4s)-4-[8-(2-fluorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol, CHLORIDE ION, Corticosteroid 11-beta-dehydrogenase isozyme 1, ... Authors: Sheriff, S. Deposit date: 2012-12-23 Release date: 2014-06-11 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD-1). ACS Med Chem Lett, 5, 2014
4IMR	Crystal structure of 3-oxoacyl (acyl-carrier-protein) reductase (target EFI-506442) from agrobacterium tumefaciens C58 with NADP bound Descriptor: 3-oxoacyl-(Acyl-carrier-protein) reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, UNKNOWN LIGAND Authors: Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Al Obaidi, N.F, Stead, M, Love, J, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) Deposit date: 2013-01-03 Release date: 2013-01-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Crystal Structure of 3-Oxoacyl (Acyl-Carrier-Protein) Reductase Atu5465 from Agrobacterium Tumefaciens To be Published
4FD3	Crystal structure of apo-formed ymtOAR1 Descriptor: 3-oxoacyl-[acyl-carrier-protein] reductase Authors: Zhang, Y, Gao, Y, Ning, F, Niu, L, Teng, M. Deposit date: 2012-05-26 Release date: 2013-06-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of apo-formed ymtOAR1 To be Published
8A7S	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal NADP bound Descriptor: MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-06-21 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.542 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AEQ	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal R773Q variant Descriptor: Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AET	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal E779W variant Descriptor: SULFATE ION, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AEW	Malonyl-CoA reductase from Chloroflexus aurantiacus - N-terminal Apo Descriptor: Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8A8T	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal NADP and malonate bound Descriptor: MALONATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-06-24 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8A30	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal Apo Descriptor: MAGNESIUM ION, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-06-06 Release date: 2023-04-05 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AEO	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal R773A variant Descriptor: SULFATE ION, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.76 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8AER	Malonyl-CoA reductase from Chloroflexus aurantiacus - C-terminal Y731A variant Descriptor: MAGNESIUM ION, Short-chain dehydrogenase/reductase SDR Authors: Kabasakal, B.V, Murray, J.W. Deposit date: 2022-07-13 Release date: 2023-04-05 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction. Biochimie, 219, 2023
8J29	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2A	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ Descriptor: GLYCEROL, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2D	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ Descriptor: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2C	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published

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