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4BB6

Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors

Summary for 4BB6
Entry DOI10.2210/pdb4bb6/pdb
Related1XU7 1XU9 2BEL 4BB5
DescriptorCORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, ... (5 entities in total)
Functional Keywordsoxidoreductase, bhsd
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationEndoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
Total number of polymer chains2
Total formula weight67383.20
Authors
Goldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C. (deposition date: 2012-09-20, release date: 2012-11-28, Last modification date: 2012-12-26)
Primary citationGoldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C.
Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors
J.Med.Chem., 55:10652-, 2012
Cited by
PubMed: 23153367
DOI: 10.1021/JM3013163
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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