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6EYD	Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Kouba, T, Barvik, I, Krasny, L. Deposit date: 2017-11-11 Release date: 2018-12-12 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.22 Å) Cite: The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
4LK0	Crystal Structure Analysis of the E.coli holoenzyme/T7 Gp2 complex Descriptor: Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2013-07-05 Release date: 2013-11-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.9103 Å) Cite: Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of sigma 70 domain 1.1. Proc.Natl.Acad.Sci.USA, 110, 2013
3WOD	RNA polymerase-gp39 complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Tagami, S, Sekine, S, Minakhin, L, Esyunina, D, Akasaka, R, Shirouzu, M, Kulbachinskiy, A, Severinov, K, Yokoyama, S. Deposit date: 2013-12-26 Release date: 2014-03-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural basis for promoter specificity switching of RNA polymerase by a phage factor. Genes Dev., 28, 2014
6FBV	Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Das, K, Lin, W, Ebright, E. Deposit date: 2017-12-19 Release date: 2018-02-28 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
3LEV	HIV-1 antibody 2F5 in complex with epitope scaffold ES2 Descriptor: 2F5 ANTIBODY HEAVY CHAIN, 2F5 ANTIBODY LIGHT CHAIN, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Baker, D, Wyatt, R, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
3LES	2F5 Epitope scaffold ES2 Descriptor: RNA polymerase sigma factor, SULFATE ION Authors: Ofek, G, Guenaga, F.J, Schief, W.R, Skinner, J, Wyatt, R, Baker, D, Kwong, P.D. Deposit date: 2010-01-15 Release date: 2010-09-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Elicitation of structure-specific antibodies by epitope scaffolds. Proc.Natl.Acad.Sci.USA, 107, 2010
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
8DY7	Streptomyces venezuelae RNAP transcription open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (71-MER), DNA (78-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
8DY9	Streptomyces venezuelae RNAP unconstrained open promoter complex with WhiA and WhiB transcription factors Descriptor: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lilic, M, Campbell, E.A. Deposit date: 2022-08-03 Release date: 2023-03-01 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB. Proc.Natl.Acad.Sci.USA, 120, 2023
3DXJ	Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... Authors: Das, K, Arnold, E. Deposit date: 2008-07-24 Release date: 2008-10-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135, 2008
2BE5	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-10-22 Release date: 2005-11-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
3EQL	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I. Deposit date: 2008-09-30 Release date: 2008-10-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Transcription inactivation through local refolding of the RNA polymerase structure. Nature, 457, 2009
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
2CW0	Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E. Deposit date: 2005-06-15 Release date: 2005-09-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation Cell(Cambridge,Mass.), 122, 2005
8JO2	Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA Descriptor: DNA (65-MER), DNA-binding transcriptional regulator BasR, DNA-directed RNA polymerase subunit alpha, ... Authors: Lou, Y.-C, Huang, H.-Y, Chen, C, Wu, K.-P. Deposit date: 2023-06-06 Release date: 2023-08-30 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.74 Å) Cite: Structural basis of transcriptional activation by the OmpR/PhoB-family response regulator PmrA. Nucleic Acids Res., 51, 2023
7ZF2	Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. Deposit date: 2022-03-31 Release date: 2023-02-08 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
7F0R	Cryo-EM structure of Pseudomonas aeruginosa SutA transcription activation complex Descriptor: DNA (70-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: He, D.W, You, L.L, Zhang, Y. Deposit date: 2021-06-06 Release date: 2022-07-27 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.8 Å) Cite: Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding. Nat Commun, 13, 2022
4G7H	Crystal structure of Thermus thermophilus transcription initiation complex Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
8AD1	RNA polymerase at U-rich pause bound to RNA putL triple mutant - pause prone, closed clamp state Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Dey, S, Weixlbaumer, A. Deposit date: 2022-07-07 Release date: 2022-10-19 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
4G7O	Crystal structure of Thermus thermophilus transcription initiation complex containing 2 nt of RNA Descriptor: 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-R(*GP*A)-3', ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.993 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
4G7Z	Crystal structure of Thermus thermophilus transcription initiation complex containing 5-BrU at template-strand position +1 Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*(BRU)P*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', DNA-directed RNA polymerase subunit alpha, ... Authors: Zhang, Y, Ebright, R.H. Deposit date: 2012-07-20 Release date: 2012-10-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.815 Å) Cite: Structural basis of transcription initiation. Science, 338, 2012
8K60	Cryo-EM structure of Streptomyces coelicolor transcription initiation complex with the global transcription factor AfsR Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Shi, J. Deposit date: 2023-07-24 Release date: 2024-07-31 Last modified: 2024-08-21 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural insights into transcription activation of the Streptomyces antibiotic regulatory protein, AfsR. Iscience, 27, 2024
8Q3I	Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Koval, T, Krasny, L, Dohnalek, J, Kouba, T. Deposit date: 2023-08-04 Release date: 2024-08-14 Method: ELECTRON MICROSCOPY (3.11 Å) Cite: Molecular insights into RNA polymerase recycling by mycobacterial HelD To Be Published
7F75	Cryo-EM structure of Spx-dependent transcription activation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y, Shi, J. Deposit date: 2021-06-28 Release date: 2021-10-13 Last modified: 2022-02-16 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of transcription activation by the global regulator Spx. Nucleic Acids Res., 49, 2021
7KHE	Escherichia coli RNA polymerase and rrnBP1 promoter pre-open complex with DksA/ppGpp Descriptor: CHAPSO, DNA (46-MER), DNA (54-MER), ... Authors: Shin, Y, Qayyum, M.Z, Murakami, K.S. Deposit date: 2020-10-21 Release date: 2020-12-09 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Structural basis of ribosomal RNA transcription regulation. Nat Commun, 12, 2021

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