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3EQL

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin

Summary for 3EQL
Entry DOI10.2210/pdb3eql/pdb
Related1IW7 1SMY 2A68 2A69 2A6E 2A6H 2BE5
DescriptorDNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (9 entities in total)
Functional Keywordsrna polymerase holoenzyme, myxopyronin, antibiotic, transcription regulation, dna-directed rna polymerase, nucleotidyltransferase, transcription, transferase, dna-binding, sigma factor
Biological sourceThermus thermophilus
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Total number of polymer chains12
Total formula weight854440.40
Authors
Vassylyev, D.G.,Vassylyeva, M.N.,Artsimovitch, I. (deposition date: 2008-09-30, release date: 2008-10-28, Last modification date: 2023-09-06)
Primary citationBelogurov, G.A.,Vassylyeva, M.N.,Sevostyanova, A.,Appleman, J.R.,Xiang, A.X.,Lira, R.,Webber, S.E.,Klyuyev, S.,Nudler, E.,Artsimovitch, I.,Vassylyev, D.G.
Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457:332-335, 2009
Cited by
PubMed: 18946472
DOI: 10.1038/nature07510
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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