PDB: 259 件ウェブページステータス検索Chemie searchBIRD

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6YYF	Crystal Structure of 5-chloroindoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 5-chloranyl-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-05-05 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Optimising crystallographic systems for structure-guided drug discovery To Be Published
6YYG	Crystal Structure of 5-(trifluoromethoxy)indoline-2,3-dione covalently bound to the PH domain of Bruton's tyrosine kinase mutant R28C 分子名称: 5-(trifluoromethyloxy)-1,3-dihydroindol-2-one, MAGNESIUM ION, Tyrosine-protein kinase BTK, ... 著者 Brear, P, Wagstaff, J, Hyvonen, M. 登録日 2020-05-05 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Optimising crystallographic systems for structure-guided drug discovery To Be Published
3LJU	Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3 分子名称: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION 著者 Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-01-26 公開日 2010-11-24 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Proc.Natl.Acad.Sci.USA, 107, 2010
5H3D	Helical structure of membrane tubules decorated by ACAP1 (BARPH doamin) protein by cryo-electron microscopy and MD simulation 分子名称: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 著者 Chan, C, Pang, X.Y, Zhang, Y, Sun, F, Fan, J. 登録日 2016-10-22 公開日 2019-01-16 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (14 Å) 主引用文献 ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages. Plos Comput.Biol., 15, 2019
4BBK	Structural and functional characterisation of the kindlin-1 pleckstrin homology domain 分子名称: FERMITIN FAMILY HOMOLOG 1, GLYCEROL 著者 Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C. 登録日 2012-09-25 公開日 2012-11-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain J.Biol.Chem., 287, 2012
7AX3	CryoEM structure of the super-constricted two-start dynamin 1 filament 分子名称: Dynamin-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Liu, J.W, Zhang, P.J. 登録日 2020-11-09 公開日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 CryoEM structure of the super-constricted two-start dynamin 1 filament. Nat Commun, 12, 2021
3MPX	Crystal structure of the DH and PH-1 domains of human FGD5 分子名称: FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION 著者 Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-04-27 公開日 2010-06-23 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the DH and PH-1 domains of human FGD5 TO BE PUBLISHED
6OLU	RIAM RA-PH core structure in the P212121 space group 分子名称: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 著者 Wu, J. 登録日 2019-04-17 公開日 2020-04-22 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Structure, 29, 2021
6O6H	RIAM cc-RA-PH structure in the P21212 space group 分子名称: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 著者 Wu, J. 登録日 2019-03-06 公開日 2020-09-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure, 2020
4CKH	Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy 分子名称: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 著者 Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F. 登録日 2014-01-06 公開日 2014-10-15 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (17 Å) 主引用文献 A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature. Dev.Cell, 31, 2014
3MDB	Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4 分子名称: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, Kinesin-like protein KIF13B, ... 著者 Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2010-03-30 公開日 2010-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.952 Å) 主引用文献 Crystal structure of the ternary complex of full length centaurin alpha-1, KIF13B FHA domain, and IP4 to be published
4CKG	Helical reconstruction of ACAP1(BAR-PH domain) decorated membrane tubules by cryo-electron microscopy 分子名称: ARF-GAP WITH COILED-COIL, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1 著者 Pang, X.Y, Fan, J, Zhang, Y, Zhang, K, Gao, B.Q, Ma, J, Li, J, Deng, Y.C, Zhou, Q.J, Hsu, V, Sun, F. 登録日 2014-01-06 公開日 2014-10-15 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (15 Å) 主引用文献 A Ph Domain in Acap1 Possesses Key Features of the Bar Domain in Promoting Membrane Curvature. Dev.Cell, 31, 2014
4GMV	Crystal Structure of the coiled-coil, RA and PH domains of Lamellipodin 分子名称: Ras-associated and pleckstrin homology domains-containing protein 1 著者 Chang, Y.C.E, Wu, J. 登録日 2012-08-16 公開日 2012-11-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.403 Å) 主引用文献 Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell, 4, 2013
4GN1	Crystal Structure of the RA and PH domains of Lamellipodin 分子名称: MALONATE ION, Ras-associated and pleckstrin homology domains-containing protein 1 著者 Chang, Y.C.E, Wu, J. 登録日 2012-08-16 公開日 2012-11-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling. Protein Cell, 4, 2013
4GZU	Crystal structure of the DH-PH-PH domain of FARP2 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 2 著者 He, X, Zhang, X. 登録日 2012-09-06 公開日 2013-03-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4H6Y	Crystal structure of the DH-PH-PH domain of FARP1 分子名称: FERM, RhoGEF and pleckstrin domain-containing protein 1 著者 He, X, Zhang, X. 登録日 2012-09-19 公開日 2013-03-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4.09 Å) 主引用文献 Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. Structure, 21, 2013
4H8S	Crystal structure of human APPL2BARPH domain 分子名称: DCC-interacting protein 13-beta 著者 Martin, J.L, King, G.J. 登録日 2012-09-23 公開日 2012-10-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Membrane Curvature Protein Exhibits Interdomain Flexibility and Binds a Small GTPase. J.Biol.Chem., 287, 2012
1NTY	Crystal structure of the first DH/PH domain of Trio to 1.7 A 分子名称: Triple functional domain protein 著者 Skowronek, K.R, Zheng, Y, Nassar, N. 登録日 2003-01-30 公開日 2004-06-29 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. J.Biol.Chem., 279, 2004
1QQG	CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1 分子名称: INSULIN RECEPTOR SUBSTRATE 1 著者 Dhe-Paganon, S, Shoelson, S.E. 登録日 1999-06-04 公開日 1999-08-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proc.Natl.Acad.Sci.USA, 96, 1999
8S93	Crystal structure of the PH-TH/kinase complex of Bruton's tyrosine kinase 分子名称: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, GLYCEROL, Tyrosine-protein kinase BTK, ... 著者 Lin, D.Y, Andreotti, A.H. 登録日 2023-03-27 公開日 2023-08-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
4K2P	The Structure of a Quintuple Mutant of the Tiam1 PH-CC-Ex Domain 分子名称: CALCIUM ION, T-lymphoma invasion and metastasis-inducing protein 1 著者 Joshi, M, Gakhar, L, Fuentes, E.J. 登録日 2013-04-09 公開日 2013-07-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 High-resolution structure of the Tiam1 PHn-CC-Ex domain. Acta Crystallogr.,Sect.F, 69, 2013
8SZ8	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state (full helix) 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-05-27 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8T0K	Cryo-EM of the GDP-bound human dynamin (full-length) polymer assembled on the membrane in the super constricted state 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-06-01 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.58 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8SXZ	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state 分子名称: Dynamin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-05-24 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.26 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024
8SZ7	Cryo-EM of the GDP-bound human dynamin polymer assembled on the membrane in the super constricted state showing the second PH domain 分子名称: Dynamin-1 著者 Jimah, J.R, Canagarajah, B.J, Hinshaw, J.E. 登録日 2023-05-27 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Cryo-EM structures of membrane-bound dynamin in a post-hydrolysis state primed for membrane fission. Dev.Cell, 2024

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