6QWE
| |
8R7M
| CTX-M14 in complex with boric acid and 1,2-diol boric ester | 分子名称: | BORIC ACID, Beta-lactamase, GLYCEROL, ... | 著者 | Werner, N, Prester, A, Hinrichs, W, Perbandt, M, Betzel, C. | 登録日 | 2023-11-26 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Time-resolved crystallography of boric acid binding to the active site serine of the Beta-lactamase CTX-M-14 and subsequent 1,2-diol esterification To Be Published
|
|
6AFP
| Crystal structure of class A b-lactamase, PenL, variant Asn136Asp, from Burkholderia thailandensis, in complex with ceftazidime-like boronic acid | 分子名称: | ACETATE ION, Beta-lactamase, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | 著者 | Cao, T.-P, Choi, J.M, Lee, S.H. | 登録日 | 2018-08-08 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | 主引用文献 | Non-catalytic-Region Mutations Conferring Transition of Class A beta-Lactamases Into ESBLs. Front Mol Biosci, 2020
|
|
6QW7
| Crystal structure of L2 complexed with relebactam (16 hour soak) | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, D-SERINE | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2019-03-05 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam. Antimicrob.Agents Chemother., 63, 2019
|
|
6QW9
| Crystal structure of KPC-2 complexed with relebactam (16 hour soak) | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, (2~{S})-5-azanylidene-2-(piperidin-4-ylcarbamoyl)piperidine-1-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2019-03-05 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam. Antimicrob.Agents Chemother., 63, 2019
|
|
6QWC
| Crystal structure of KPC-4 complexed with relebactam (1 hour soak) | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2019-03-05 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Molecular Basis of Class A beta-Lactamase Inhibition by Relebactam. Antimicrob.Agents Chemother., 63, 2019
|
|
6AFO
| |
3E2L
| Crystal Structure of the KPC-2 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) | 分子名称: | Beta-lactamase inhibitory protein, Carbapenemase | 著者 | Hanes, M.S, Jude, K.M, Berger, J.M, Kirsch, J.F, Bonomo, R.A, Handel, T.M. | 登録日 | 2008-08-05 | 公開日 | 2009-08-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein Biochemistry, 48, 2009
|
|
1FQG
| |
3Q1F
| CTX-M-9 S70G in complex with hydrolyzed piperacillin | 分子名称: | Beta-lactamase, Hydrolyzed piperacillin | 著者 | Leyssne, D, Delmas, J, Coignoux, A, Robin, F, Bonnet, R. | 登録日 | 2010-12-17 | 公開日 | 2011-12-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | CTX-M-9 S70G mutant in complex with hydrolyzed piperacillin To be Published
|
|
1G68
| PSE-4 CARBENICILLINASE, WILD TYPE | 分子名称: | BETA-LACTAMASE PSE-4, SULFATE ION | 著者 | Lim, D, Sanschagrin, F, Passmore, L, De Castro, L, Levesque, R.C, Strynadka, N.C.J. | 登録日 | 2000-11-03 | 公開日 | 2001-02-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Biochemistry, 40, 2001
|
|
3E2K
| Crystal Structure of the KPC-2 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) | 分子名称: | Beta-lactamase inhibitory protein, Carbapenemase | 著者 | Hanes, M.S, Jude, K.M, Berger, J.M, Bonomo, R.A, Handel, T.M. | 登録日 | 2008-08-05 | 公開日 | 2009-08-04 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein Biochemistry, 48, 2009
|
|
3QHY
| Structural, thermodynamic and kinetic analysis of the picomolar binding affinity interaction of the beta-lactamase inhibitor protein-II (BLIP-II) with class A beta-lactamases | 分子名称: | Beta-lactamase, Beta-lactamase inhibitory protein II | 著者 | Brown, N.G, Chow, D.C, Sankaran, B, Zwart, P, Prasad, B.V.V, Palzkill, T, Berkeley Structural Genomics Center (BSGC) | 登録日 | 2011-01-26 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases. J.Biol.Chem., 286, 2011
|
|
1GHM
| Structures of the acyl-enzyme complex of the staphylococcus aureus beta-lactamase mutant GLU166ASP:ASN170GLN with degraded cephaloridine | 分子名称: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, BETA-LACTAMASE, CARBONATE ION, ... | 著者 | Chen, C.C.H, Herzberg, O. | 登録日 | 2000-12-19 | 公開日 | 2001-04-04 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structures of the acyl-enzyme complexes of the Staphylococcus aureus beta-lactamase mutant Glu166Asp:Asn170Gln with benzylpenicillin and cephaloridine. Biochemistry, 40, 2001
|
|
1GHP
| |
1GHI
| |
1G6A
| PSE-4 CARBENICILLINASE, R234K MUTANT | 分子名称: | BETA-LACTAMASE PSE-4, SULFATE ION | 著者 | Lim, D, Sanschagrin, F, Passmore, L, De Castro, L, Levesque, R.C, Strynadka, N.C.J. | 登録日 | 2000-11-03 | 公開日 | 2001-02-21 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Insights into the molecular basis for the carbenicillinase activity of PSE-4 beta-lactamase from crystallographic and kinetic studies. Biochemistry, 40, 2001
|
|
6SP6
| Ultra-high Resolution Crystal Structure of the CTX-M-15 Extended-Spectrum beta-Lactamase in Complex with Taniborbactam (VNRX-5133) | 分子名称: | (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase, ... | 著者 | Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S. | 登録日 | 2019-08-31 | 公開日 | 2020-01-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-beta-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J.Med.Chem., 63, 2020
|
|
3RXX
| KPC-2 carbapenemase in complex with 3-NPBA | 分子名称: | 3-NITROPHENYLBORONIC ACID, Carbepenem-hydrolyzing beta-lactamase KPC | 著者 | Ke, W, van den Akker, F. | 登録日 | 2011-05-10 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob.Agents Chemother., 56, 2012
|
|
3DWZ
| Meropenem Covalent Adduct with TB Beta-lactamase | 分子名称: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | 登録日 | 2008-07-23 | 公開日 | 2009-03-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323, 2009
|
|
6TD1
| Crystal structure of VNRX-5133 (taniborbactam) bound to KPC-2 | 分子名称: | (3~{R})-3-[2-[4-(2-azanylethylamino)cyclohexyl]ethanoylamino]-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2019-11-07 | 公開日 | 2020-01-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11, 2020
|
|
6TD0
| Crystal structure of vaborbactam bound to KPC-2 | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2019-11-07 | 公開日 | 2020-01-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | 主引用文献 | Cyclic boronates as versatile scaffolds for KPC-2 beta-lactamase inhibition. Rsc Med Chem, 11, 2020
|
|
3D4F
| SHV-1 beta-lactamase complex with LN1-255 | 分子名称: | (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | 著者 | Pattanaik, P, Bethel, C.R, Hujer, A.M, Bonomo, R.A, Buynak, J.D, van den Akker, F. | 登録日 | 2008-05-14 | 公開日 | 2009-02-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem., 284, 2009
|
|
3RXW
| KPC-2 carbapenemase in complex with PSR3-226 | 分子名称: | (2S,3R)-4-(2-amino-2-oxoethoxy)-3-(dihydroxy-lambda~4~-sulfanyl)-3-methyl-4-oxo-2-{[(1E)-3-oxoprop-1-en-1-yl]amino}butanoic acid, CITRIC ACID, Carbepenem-hydrolyzing beta-lactamase KPC | 著者 | Ke, W, van den Akker, F. | 登録日 | 2011-05-10 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Crystal structures of KPC-2 {beta}-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrob.Agents Chemother., 56, 2012
|
|
6TS9
| Crystal structure of GES-5 carbapenemase | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, Beta-lactamase, ... | 著者 | Maso, L, Tondi, D, Klein, R, Montanari, M, Bellio, C, Celenza, G, Brenk, R, Cendron, L. | 登録日 | 2019-12-20 | 公開日 | 2020-03-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Targeting the Class A Carbapenemase GES-5 via Virtual Screening. Biomolecules, 10, 2020
|
|