PDB: 970 件ウェブページステータス検索Chemie searchBIRD

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4XFB	cysteine dioxygenase variant - C93A at pH 8.0 unliganded 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
5FH2	The structure of rat cytosolic PEPCK variant E89Q in complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
4XFA	cysteine dioxygenase variant - Y157F at pH 8.0 in complex with homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structures of Mammalian Cysteine Dioxygenase Variants Missing the Cys-Tyr Crosslink To Be Published
4XFI	cysteine dioxygenase variant - Y157F at pH 6.2 with homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cysteine dioxygenase type 1, FE (III) ION 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
4XFF	cysteine dioxygenase variant - Y157F at pH 6.2 with dithionite 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (III) ION, ... 著者 Driggers, C.M, Karplus, P.A. 登録日 2014-12-26 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
5KOY	Mouse pgp 34 linker deleted bound with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-01 公開日 2016-12-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.85 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5KO2	Mouse pgp 34 linker deleted mutant Hg derivative 分子名称: MERCURY (II) ION, Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-06-29 公開日 2016-11-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5FH5	The structure of rat cytosolic PEPCK variant E89Q in complex with phosphoglycolate and GDP 分子名称: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5KPD	Mouse pgp 34 linker deleted double EQ mutant 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-03 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5FH3	The structure of rat cytosolic PEPCK variant E89A in complex with oxalic acid and GTP 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH1	The structure of rat cytosolic PEPCK variant E89D in complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-12-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5KPI	Mouse native PGP 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-04 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
5FH0	The structure of rat cytosolic PEPCK variant E89A complex with GTP 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FH4	The structure of rat cytosolic PEPCK variant E89D in complex with beta-sulfopyruvate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2015-12-21 公開日 2016-11-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase. Biochemistry, 55, 2016
5FDB	Iron free rat cysteine dioxygenase R60QC164R variant 分子名称: Cysteine dioxygenase type 1 著者 Fellner, M, Davies, C.G, Tchesnokov, E.P, Jameson, G.N.L, Wilbanks, S.M. 登録日 2015-12-16 公開日 2016-12-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Iron free rat cysteine dioxygenase R60QC164R variant To be published
7B5R	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27 分子名称: Cullin-1, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-07 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 分子名称: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-04 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
5KPJ	Mouse pgp methylated protein 分子名称: Multidrug resistance protein 1A 著者 Xia, D, Esser, L, Zhou, F. 登録日 2016-07-04 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J. Biol. Chem., 292, 2017
7AXW	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 1-aminoisoquinoline and PKI (5-24) 分子名称: ISOQUINOLIN-1-AMINE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
7AXV	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with 5-isoquinolinesulfonic acid and PKI (5-24) 分子名称: DIMETHYL SULFOXIDE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ... 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
7AXT	Crystal structure of the cAMP-dependent protein kinase A cocrystallized with isoquinoline-5-carboxylic acid and PKI (5-24) 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, isoquinoline-5-carboxylic acid 著者 Oebbeke, M, Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published
5LCP	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with Fasudil (M77) 分子名称: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, DIMETHYL SULFOXIDE, METHANOL, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-06-22 公開日 2018-01-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.433 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with Fasudil (M77) To Be Published
5LCT	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a R-methyl-piperazine substituted Fasudil-derivative (Ligand 02) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-[(2~{R})-2-methylpiperazin-1-yl]sulfonylisoquinoline, METHANOL, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-06-22 公開日 2018-01-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.615 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published
5LCU	Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with a S-methyl-piperazine substituted Fasudil-derivative (Ligand 01) 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, METHANOL, ... 著者 Wienen-Schmidt, B, Heine, A, Klebe, G. 登録日 2016-06-22 公開日 2018-01-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.579 Å) 主引用文献 Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives To Be Published
7BW0	Active human TGR5 complex with a synthetic agonist 23H 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, G, Wang, X.K, Chen, Q, Hu, H.L, Ren, R.B. 登録日 2020-04-12 公開日 2020-09-02 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein. Signal Transduct Target Ther, 5, 2020

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