PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

---

7RUO	Crystal structure of human UTP15 分子名称: U3 small nucleolar RNA-associated protein 15 homolog, UNKNOWN ATOM OR ION 著者 Dehghani-Tafti, S, Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2021-08-17 公開日 2021-11-10 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of human UTP15 To Be Published
6QTR	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTT	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor homolog 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6WJQ	Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 分子名称: 3-phosphoinositide-dependent protein kinase 1, WD repeat-containing protein 5 著者 Zhao, B, Fesik, S. 登録日 2020-04-14 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Crystal structure of WDR5 in complex with the WIN peptide of PDPK1 Cell Rep, 2021
6QTQ	Crystal structure of an Arabidopsis WD40 domain in complex with photoreceptor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTX	Crystal structure of an Arabidopsis WD40 domain in complex with a flowering transcription factor homolog 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTV	Crystal structure of an Arabidopsis WD40 domain in complex with an atypical bHLH transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, MALONATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTO	Crystal structure of an Arabidopsis WD40 domain in complex with a transcription factor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6QTW	Crystal structure of an Arabidopsis WD40 domain in complex with a blue light photoreceptor 分子名称: Cryptochrome-1, E3 ubiquitin-protein ligase COP1, GLYCEROL, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019
6YVI	EED in complex with a cyano-benzofuran 分子名称: 5-fluoranyl-4-[[[8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-yl]amino]methyl]-2,3-dihydro-1-benzofuran-7-carbonitrile, CALCIUM ION, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Read, J.A. 登録日 2020-04-28 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
6YVJ	EED in complex with a triazolopyrimidine 分子名称: GLYCEROL, N-(2,3-dihydro-1-benzofuran-4-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... 著者 Read, J.A. 登録日 2020-04-28 公開日 2021-05-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase. Bioorg.Med.Chem.Lett., 39, 2021
7AXU	Structure of WDR5:CS-VIP8 cocrystal after illumination in situ 分子名称: WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXQ	Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K 分子名称: CS-VIP8, WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.562 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXX	Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature 分子名称: (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXP	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 2 分子名称: CS-VIP8, WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.432 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXS	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1 分子名称: CS-VIP8, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
8D41	Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 分子名称: (1R,2R,3S,4S)-3-[4-(4-fluorophenyl)piperazine-1-carbonyl]bicyclo[2.2.1]heptane-2-carboxylic acid, Coatomer subunit beta', GLYCEROL, ... 著者 Zeng, H, Saraon, P, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2022-06-01 公開日 2022-07-06 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of the human COPB2 WD-domain in complex with OICR-6254 To Be Published
7U9Y	WDR5 bound to 2-(3,5-dimethoxybenzyl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-1(2H)-one 分子名称: (5P)-2-[(3,5-dimethoxyphenyl)methyl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-3,4-dihydroisoquinolin-1(2H)-one, BENZAMIDINE, WD repeat-containing protein 5 著者 Rietz, T. 登録日 2022-03-11 公開日 2022-04-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
8E9F	WD repeat-containing protein 5 complexed with 4-(7-((1H-imidazol-1-yl)methyl)-5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-ethyl-N-methylquinoline-8-carboxamide (compound 10) 分子名称: 6-ethyl-4-[(5P)-7-[(1H-imidazol-1-yl)methyl]-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl]-N-methylquinoline-8-carboxamide, BENZAMIDINE, WD repeat-containing protein 5 著者 Rietz, T.A, Fesik, S.W. 登録日 2022-08-26 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models. Proc.Natl.Acad.Sci.USA, 120, 2023
7UAS	Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization 分子名称: (5P)-2-[(S)-cyclopropyl(4-methylpyridin-2-yl)methyl]-5-[1-ethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-[(2-methyl-1H-imidazol-1-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, WD repeat-containing protein 5 著者 Zhao, B. 登録日 2022-03-14 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.808 Å) 主引用文献 Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization. J.Med.Chem., 65, 2022
8F1G	Crystal structure of human WDR5 in complex with compound WM662 分子名称: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... 著者 Liu, H. 登録日 2022-11-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
8F93	WDR5 covalently modified at Y228 by (R)-2-SF 分子名称: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... 著者 Taunton, J, Craven, G.B, Chen, Y. 登録日 2022-11-23 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
8EVL	Crystal structure of alpha-COPI N-terminal WD40 domain 分子名称: Putative coatomer subunit alpha 著者 Dey, D, Hasan, S.S. 登録日 2022-10-20 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8F0E	N-terminal WD40 domain of beta'-COPI subunit with four chains in the asymmetric unit 分子名称: Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2022-11-02 公開日 2023-08-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein Expr.Purif., 212, 2023
8SZX	Crystal structure of b'-WD40 Lys17Ala mutant 分子名称: Coatomer subunit beta' 著者 Dey, D, Hasan, S.S. 登録日 2023-05-30 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs. Nat Commun, 14, 2023

<45678910111213141516171819>