PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

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6PGE	WDR5delta32 bound to ethyl 3-(4-(hydroxymethyl)-1H-imidazol-2-yl)propanoate 分子名称: 1,2-ETHANEDIOL, SULFATE ION, WD repeat-containing protein 5, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6UHZ	WDR5 in complex with Myc site fragment inhibitor 分子名称: 1-cyclohexyl-1H-benzotriazole-5-carboxylic acid, WDR5 著者 Wang, F, Fesik, S.w. 登録日 2019-09-29 公開日 2020-04-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.258 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6PG7	WDR5delta32 bound to (2-(3-methoxy-3-phenylpropyl)-1H-imidazol-4-yl)methanol 分子名称: DI(HYDROXYETHYL)ETHER, WD repeat-containing protein 5, {2-[(3S)-3-methoxy-3-phenylpropyl]-1H-imidazol-4-yl}methanol 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGD	WDR5delta32 bound to peptidomimetic 分子名称: N-acetyl-L-alanyl-5-[5-(hydroxymethyl)-1H-imidazol-2-yl]-L-norvalyl-L-valinamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGC	WDR5delta32 bound to methyl benzyl(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, methyl benzyl{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG6	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acetamide 分子名称: CHLORIDE ION, N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}acetamide, SULFATE ION, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PBG	Crystal structure of WD-repeat domain of human coatomer subunit Alpha (COPA) 分子名称: Coatomer subunit alpha, L(+)-TARTARIC ACID, UNKNOWN ATOM OR ION 著者 Halabelian, L, Zeng, H, Dong, A, Loppnau, P, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2019-06-13 公開日 2019-06-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structure of W repeat domain of human coatomer subunit Alpha (COPA) to be published
6PG3	WDR5delta23 bound to (2-butyl-1H-imidazol-4-yl)methanol 分子名称: (2-butyl-1H-imidazol-4-yl)methanol, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGF	WDR5delta32 bound to N-(4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)acrylamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}prop-2-enamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG8	WDR5delta23 bound to (2-(3-phenylpropyl)-1H-imidazol-4-yl)methanol 分子名称: CHLORIDE ION, SULFATE ION, WD repeat-containing protein 5, ... 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG5	WDR5delta32 bound to benzyl (4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, benzyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGB	WDR5delta32 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)-2-phenylacetamide 分子名称: N-{4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}-2-phenylacetamide, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG4	WDR5delta32 bound to (2-methyl-1H-imidazol-4-yl)methanol 分子名称: (2-methyl-1H-imidazol-4-yl)methanol, SULFATE ION, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PG9	WDR5delta23 bound to N-(4-(5-(hydroxymethyl)-1H-imidazol-2-yl)butyl)benzamide 分子名称: N-{4-[4-(hydroxymethyl)-1H-imidazol-2-yl]butyl}benzamide, WD repeat-containing protein 5 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6PGA	WDR5delta32 bound to methyl (4-(4-(hydroxymethyl)-1H-imidazol-2-yl)butyl)carbamate 分子名称: SULFATE ION, WD repeat-containing protein 5, methyl {4-[5-(hydroxymethyl)-1H-imidazol-2-yl]butyl}carbamate 著者 Dennis, M.L, Peat, T.S. 登録日 2019-06-24 公開日 2019-12-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening for a protein-protein interaction inhibitor to WDR5. Struct Dyn., 6, 2019
6UOZ	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction 分子名称: 5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 著者 Zhao, B. 登録日 2019-10-16 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.532 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6V3X	Crystal structure of EED in complex with PALI1-K1241me3 peptide 分子名称: PALI1 peptide, Polycomb protein EED 著者 Zhang, Q, Davidovich, C. 登録日 2019-11-26 公開日 2021-05-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nat Commun, 12, 2021
6V3Y	Crystal structure of EED in complex with PALI1-K1219me3 peptide 分子名称: PALI1 peptide, Polycomb protein EED 著者 Zhang, Q, Davidovich, C. 登録日 2019-11-26 公開日 2021-05-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. Nat Commun, 12, 2021
6OI3	Crystal structure of human WDR5 in complex with monomethyl H3R2 peptide 分子名称: GLYCEROL, Monomethyl H3R2 peptide, SULFATE ION, ... 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-08 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OFZ	Crystal structure of human WDR5 分子名称: WD repeat-containing protein 5 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-01 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OI1	Crystal structure of human WDR5 in complex with monomethyl L-arginine 分子名称: (2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]pentanoic acid, GLYCEROL, SULFATE ION, ... 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-08 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6OI2	Crystal structure of human WDR5 in complex with symmetric dimethyl-L-arginine 分子名称: GLYCEROL, N3, N4-DIMETHYLARGININE, ... 著者 Lorton, B.M, Harijan, R.K, Burgos, E, Bonanno, J.B, Almo, S.C, Shechter, D. 登録日 2019-04-08 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 A Binary Arginine Methylation Switch on Histone H3 Arginine 2 Regulates Its Interaction with WDR5. Biochemistry, 59, 2020
6W7G	Structure of EED bound to inhibitor 1056 分子名称: 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, FORMIC ACID, Polycomb protein EED, ... 著者 Petrunak, E.M, Stuckey, J.A. 登録日 2020-03-19 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63, 2020
6W7F	Structure of EED bound to inhibitor 5285 分子名称: 8-(6-cyclopropylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, GLYCEROL, Polycomb protein EED 著者 Petrunak, E.M, Stuckey, J.A. 登録日 2020-03-19 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63, 2020
6QTS	Crystal structure of a mutant Arabidopsis WD40 domain in complex with a photoreceptor 分子名称: E3 ubiquitin-protein ligase COP1, GLYCEROL, SULFATE ION, ... 著者 Hothorn, M, Lau, K. 登録日 2019-02-25 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.11 Å) 主引用文献 Plant photoreceptors and their signaling components compete for COP1 binding via VP peptide motifs. Embo J., 38, 2019

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