1G8T
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![BU of 1g8t by Molmil](/molmil-images/mine/1g8t) | SM ENDONUCLEASE FROM SERATIA MARCENSCENS AT 1.1 A RESOLUTION | Descriptor: | MAGNESIUM ION, NUCLEASE SM2 ISOFORM, SULFATE ION | Authors: | Lunin, V.V, Perbandt, M, Betzel, C.H, Mikhailov, A.M. | Deposit date: | 2000-11-21 | Release date: | 2000-12-06 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Atomic structure of the Serratia marcescens endonuclease at 1.1 A resolution and the enzyme reaction mechanism. Acta Crystallogr.,Sect.D, 56, 2000
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1ZM8
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![BU of 1zm8 by Molmil](/molmil-images/mine/1zm8) | Apo Crystal structure of Nuclease A from Anabaena sp. | Descriptor: | MANGANESE (II) ION, Nuclease, SODIUM ION, ... | Authors: | Ghosh, M, Meiss, G, Pingoud, A, London, R.E, Pedersen, L.C. | Deposit date: | 2005-05-10 | Release date: | 2005-06-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena. J.Biol.Chem., 280, 2005
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1SMN
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![BU of 1smn by Molmil](/molmil-images/mine/1smn) | |
3S5B
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![BU of 3s5b by Molmil](/molmil-images/mine/3s5b) | |
4QN0
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![BU of 4qn0 by Molmil](/molmil-images/mine/4qn0) | Crystal structure of the CPS-6 mutant Q130K | Descriptor: | Endonuclease G, mitochondrial, MAGNESIUM ION | Authors: | Lin, J.L.J, Yuan, H.S. | Deposit date: | 2014-06-17 | Release date: | 2015-06-17 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G Cell Rep, 16, 2016
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5FGW
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![BU of 5fgw by Molmil](/molmil-images/mine/5fgw) | Structure of Sda1 nuclease with bound zinc ion | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | Deposit date: | 2015-12-21 | Release date: | 2016-03-30 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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6M3T
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![BU of 6m3t by Molmil](/molmil-images/mine/6m3t) | |
1QAE
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![BU of 1qae by Molmil](/molmil-images/mine/1qae) | |
1QL0
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![BU of 1ql0 by Molmil](/molmil-images/mine/1ql0) | |
4E3Y
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![BU of 4e3y by Molmil](/molmil-images/mine/4e3y) | X-ray structure of the Serratia marcescens endonuclease at 0.95 A resolution | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Lashkov, A.A, Balaev, V.V, Gabdoulkhakov, A.G, Betzel, C, Mikhailov, A.M. | Deposit date: | 2012-03-11 | Release date: | 2013-05-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | X-ray structure of the Serratia marcescens endonuclease at 0.95 A resolution To be Published
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6LYF
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![BU of 6lyf by Molmil](/molmil-images/mine/6lyf) | |
6M3F
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![BU of 6m3f by Molmil](/molmil-images/mine/6m3f) | |
6M3U
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![BU of 6m3u by Molmil](/molmil-images/mine/6m3u) | |
6NJT
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![BU of 6njt by Molmil](/molmil-images/mine/6njt) | Mouse endonuclease G mutant - H97A | Descriptor: | CHLORIDE ION, Endonuclease G, mitochondrial, ... | Authors: | Vander Zanden, C.M, Ho, E.N, Czarny, R.S, Robertson, A.B, Ho, P.S. | Deposit date: | 2019-01-04 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res., 48, 2020
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6NJU
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![BU of 6nju by Molmil](/molmil-images/mine/6nju) | Mouse endonuclease G mutant H97A bound to A-DNA | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DNA (5'-D(CCGGCGCCGG)-3'), ... | Authors: | Vander Zanden, C.M, Ho, E.N, Czarny, R.S, Robertson, A.B, Ho, P.S. | Deposit date: | 2019-01-04 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res., 48, 2020
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3OWV
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![BU of 3owv by Molmil](/molmil-images/mine/3owv) | Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae | Descriptor: | CHLORIDE ION, DNA-entry nuclease, MAGNESIUM ION | Authors: | Moon, A.F, Midon, M, Meiss, G, Pingoud, A.M, London, R.E, Pedersen, L.C. | Deposit date: | 2010-09-20 | Release date: | 2010-12-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae. Nucleic Acids Res., 39, 2011
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5GKP
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![BU of 5gkp by Molmil](/molmil-images/mine/5gkp) | |
5GKC
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![BU of 5gkc by Molmil](/molmil-images/mine/5gkc) | The crystal structure of the CPS-6 H148A/F122A | Descriptor: | Endonuclease G, mitochondrial | Authors: | Lin, J.L, Yuan, H.S. | Deposit date: | 2016-07-04 | Release date: | 2016-11-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer. Nucleic Acids Res., 44, 2016
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6AEL
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![BU of 6ael by Molmil](/molmil-images/mine/6ael) | Crystal structure of ENPP1 in complex with 3'3'-cGAMP | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, ... | Authors: | Kato, K, Nishimasu, H, Hirano, S, Hirano, H, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-05 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nat Commun, 9, 2018
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6IID
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![BU of 6iid by Molmil](/molmil-images/mine/6iid) | Human EXOG-H140A in complex with RNA-DNA chimeric duplex | Descriptor: | DNA (5'-D(*CP*GP*TP*GP*AP*CP*AP*TP*CP*CP*CP*G)-3'), DNA/RNA (5'-R(P*CP*GP*GP*GP*A)-D(P*T)-R(P*G)-D(P*T)-R(P*CP*AP*CP*G)-3'), MAGNESIUM ION, ... | Authors: | Wu, C.C, Lin, J.L.J, Yuan, H.S. | Deposit date: | 2018-10-04 | Release date: | 2019-04-03 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.986 Å) | Cite: | A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication. Nucleic Acids Res., 47, 2019
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8GHR
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![BU of 8ghr by Molmil](/molmil-images/mine/8ghr) | Structure of human ENPP1 in complex with variable heavy domain VH27.2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ... | Authors: | Carozza, J.A, Wang, H, Solomon, P.E, Wells, J.A, Li, L. | Deposit date: | 2023-03-10 | Release date: | 2023-08-02 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Discovery of VH domains that allosterically inhibit ENPP1. Nat.Chem.Biol., 20, 2024
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2O3B
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![BU of 2o3b by Molmil](/molmil-images/mine/2o3b) | Crystal structure complex of Nuclease A (NucA) with intra-cellular inhibitor NuiA | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, NICKEL (II) ION, ... | Authors: | Ghosh, M, Meiss, G, Pingoud, A.M, London, R.E, Pedersen, L.C. | Deposit date: | 2006-12-01 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The nuclease a-inhibitor complex is characterized by a novel metal ion bridge. J.Biol.Chem., 282, 2007
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3ISM
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![BU of 3ism by Molmil](/molmil-images/mine/3ism) | Crystal structure of the EndoG/EndoGI complex: Mechanism of EndoG inhibition | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CG4930, CG8862, ... | Authors: | Loll, B, Gebhardt, M, Wahle, E, Meinhart, A. | Deposit date: | 2009-08-26 | Release date: | 2009-09-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition. Nucleic Acids Res., 37, 2009
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5FGU
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![BU of 5fgu by Molmil](/molmil-images/mine/5fgu) | Structure of Sda1 nuclease apoprotein as an EGFP fixed-arm fusion | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Green fluorescent protein,Extracellular streptodornase D, ... | Authors: | Moon, A.F, Krahn, J.M, Xun, L, Cuneo, M.J, Pedersen, L.C. | Deposit date: | 2015-12-21 | Release date: | 2016-03-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.896 Å) | Cite: | Structural characterization of the virulence factor Sda1 nuclease from Streptococcus pyogenes. Nucleic Acids Res., 44, 2016
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7R6V
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![BU of 7r6v by Molmil](/molmil-images/mine/7r6v) | Human EXOG complexed with dRP-containing DNA | Descriptor: | DNA (5'-D(*CP*GP*CP*AP*CP*GP*TP*CP*AP*GP*AP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*GP*TP*GP*CP*G)-3'), MAGNESIUM ION, ... | Authors: | Szymanski, M.R, Yin, Y.W. | Deposit date: | 2021-06-23 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Human EXOG possesses strong AP hydrolysis activity To Be Published
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