8GHR

Structure of human ENPP1 in complex with variable heavy domain VH27.2

Summary for 8GHR

Entry DOI	10.2210/pdb8ghr/pdb
EMDB information	40047
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form, Immunoglobulin gamma-1 heavy chain fusion, VH27, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	phosphodiesterase, inhibitor, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	261723.97
Authors	Carozza, J.A.,Wang, H.,Solomon, P.E.,Wells, J.A.,Li, L. (deposition date: 2023-03-10, release date: 2023-08-02, Last modification date: 2024-01-03)
Primary citation	Solomon, P.E.,Bracken, C.J.,Carozza, J.A.,Wang, H.,Young, E.P.,Wellner, A.,Liu, C.C.,Sweet-Cordero, E.A.,Li, L.,Wells, J.A. Discovery of VH domains that allosterically inhibit ENPP1. Nat.Chem.Biol., 20:30-41, 2024 Cited by PubMed: 37400538 DOI: 10.1038/s41589-023-01368-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation