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2BYY	E.coli KAS I H298E Mutation Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-09 Release date: 2006-02-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BUH	E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I, 120 K Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION Authors: Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-06-13 Release date: 2005-06-16 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BUI	E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I IN COMPLEX WITH OCTANOIC ACID, 120K Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, OCTANOIC ACID (CAPRYLIC ACID) Authors: Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-06-13 Release date: 2005-06-16 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BYX	KAS I LYS328ALA Mutant in complex with fatty acid Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-09 Release date: 2006-02-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BYW	Structure of Escherichia coli beta-ketoacyl (acyl carrier protein) synthase I LYS328ALA mutant Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-09 Release date: 2005-09-09 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BZ3	Structure of E.coli KAS I H298E mutant in complex with C12 fatty acid Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID, ... Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-10 Release date: 2006-02-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BZ4	structure of E.coli KAS I H298Q mutant Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, SULFATE ION Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-10 Release date: 2006-02-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2BYZ	Structure of E.coli KAS I H298Q mutant in complex with C12 fatty acid Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID Authors: Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. Deposit date: 2005-08-09 Release date: 2006-02-01 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
2CF2	Architecture of mammalian fatty acid synthase Descriptor: FATTY ACID SYNTHASE, DH DOMAIN, ER DOMAIN, ... Authors: Maier, T, Jenni, S, Ban, N. Deposit date: 2006-02-14 Release date: 2006-03-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (4.3 Å) Cite: Architecture of Mammalian Fatty Acid Synthase at 4.5 A Resolution. Science, 311, 2006
2C9H	Structure of mitochondrial beta-ketoacyl synthase Descriptor: MITOCHONDRIAL BETA-KETOACYL SYNTHASE, NICKEL (II) ION Authors: Bunkoczi, G, Wu, X, Smee, C, Gileadi, O, Arrowsmith, C, Edwards, A, Sundstrom, M, Weigelt, J, von Delft, F, Oppermann, U. Deposit date: 2005-12-12 Release date: 2005-12-13 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure of Mitochondrial Beta-Ketoacyl Synthase To be Published
2GFX	Structure of E. coli FabF(C163Q) in complex with Platensimycin Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFW	Structure of wild type E. coli FabF (KASII) Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFY	Structure of E. coli FabF(K335A) mutant with covalently linked dodecanoic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, LAURIC ACID Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFV	Structure of E. coli FabF (KASII) C163Q mutant Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Soisson, S.M, Parthasarathy, G. Deposit date: 2006-03-23 Release date: 2006-05-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
8CV1	ACP1-KS-AT domains of mycobacterial Pks13 Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND Authors: Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. Deposit date: 2022-05-17 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CV0	KS-AT domains of mycobacterial Pks13 with outward AT conformation Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND Authors: Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. Deposit date: 2022-05-17 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CUY	ACP1-KS-AT domains of mycobacterial Pks13 Descriptor: 4'-PHOSPHOPANTETHEINE, Polyketide synthase PKS13, UNKNOWN LIGAND Authors: Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. Deposit date: 2022-05-17 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CUZ	KS-AT domains of mycobacterial Pks13 with inward AT conformation Descriptor: Polyketide synthase PKS13, UNKNOWN LIGAND Authors: Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M. Deposit date: 2022-05-17 Release date: 2023-02-15 Last modified: 2023-03-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat.Struct.Mol.Biol., 30, 2023
8CJH	Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin Descriptor: Colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK Authors: Bonhomme, S, Dessen, A, Macheboeuf, P. Deposit date: 2023-02-13 Release date: 2023-04-26 Last modified: 2023-06-14 Method: X-RAY DIFFRACTION (2.982 Å) Cite: Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin. Structure, 31, 2023
8COV	Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-28 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COU	Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid Descriptor: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-28 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.68 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN2	Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN8	apo Pseudomonas aeruginosa FabF C164A mutant Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2 Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN4	Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... Authors: Georgiou, C, Brenk, R. Deposit date: 2023-02-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.67 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNE	Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... Authors: Georgiou, C, Brenk, R, Espeland, L.O. Deposit date: 2023-02-22 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (1.57 Å) Cite: New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023

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