5AIV
 
 | | Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor. | | Descriptor: | 3-(1H-indol-4-yl)-N-(3-methoxypropyl)-1,2,4-oxadiazole-5-carboxamide, GLUTATHIONE, HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE, ... | | Authors: | Edfeldt, F, Evenas, J, Lepisto, M, Ward, A, Petersen, J, Wissler, L, Rohman, M, Sivars, U, Svensson, K, Perry, M, Feierberg, I, Zhou, X, Hansson, T, Narjes, F. | | Deposit date: | 2015-02-17 | | Release date: | 2015-06-03 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds).
Bioorg.Med.Chem.Lett., 25, 2015
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8GS8
 | | cryo-EM structure of the human respiratory complex II | | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | | Authors: | Du, Z, Zhou, X, Lai, Y, Xu, J, Zhang, Y, Zhou, S, Liu, F, Gao, Y, Gong, H, Rao, Z. | | Deposit date: | 2022-09-05 | | Release date: | 2023-05-10 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structure of the human respiratory complex II.
Proc.Natl.Acad.Sci.USA, 120, 2023
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7CYG
 | | Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation | | Descriptor: | Transporter, sodium/bile acid symporter family | | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-09-03 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.198 Å) | | Cite: | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
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7CYK
 | | Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation | | Descriptor: | MERCURY (II) ION, Transporter, sodium/bile acid symporter family | | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-09-03 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.785 Å) | | Cite: | An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
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7Y9B
 | | Crystal structure of the membrane (M) protein of a SARS-COV-2-related coronavirus | | Descriptor: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Membrane protein | | Authors: | Wang, X, Sun, Z, Zhou, X. | | Deposit date: | 2022-06-24 | | Release date: | 2022-08-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.214 Å) | | Cite: | Crystal structure of the membrane (M) protein from a bat betacoronavirus.
Pnas Nexus, 2, 2023
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7Y96
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8HUZ
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8JED
 | | Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors | | Descriptor: | mRNA-capping enzyme regulatory subunit OPG124 | | Authors: | Wang, D, Zhao, R, Shu, W, Hu, W, Wang, M, Cao, J, Zhou, X. | | Deposit date: | 2023-05-15 | | Release date: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors.
Int.J.Biol.Macromol., 253, 2023
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8JIX
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7DIX
 | | Crystal structure of LeuT in lipidic cubic phase at pH 5 | | Descriptor: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DJC
 | | Crystal structure of the G26C/Q250A mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-20 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DJ2
 | | Crystal structure of the G26C/E290S mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DJ1
 | | Crystal structure of the G26C mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.528 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DII
 | | Crystal structure of LeuT in lipidic cubic phase at pH 7 | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.403 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DPW
 | | Structural basis for ligand binding modes of CTP synthase | | Descriptor: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | | Deposit date: | 2020-12-21 | | Release date: | 2021-09-15 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Structural basis for ligand binding modes of CTP synthase.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7DPT
 | | Structural basis for ligand binding modes of CTP synthase | | Descriptor: | 6-DIAZENYL-5-OXO-L-NORLEUCINE, ADENOSINE-5'-DIPHOSPHATE, CTP synthase, ... | | Authors: | Liu, J.L, Zhou, X, Guo, C.J, Chang, C.C. | | Deposit date: | 2020-12-21 | | Release date: | 2021-09-15 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Structural basis for ligand binding modes of CTP synthase.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7F5X
 | | GK domain of Drosophila P5CS filament with glutamate | | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GAMMA-L-GLUTAMIC ACID | | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | Deposit date: | 2021-06-23 | | Release date: | 2022-04-06 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7F5U
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7F5V
 | | Drosophila P5CS filament with glutamate, ATP, and NADPH | | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase | | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | Deposit date: | 2021-06-22 | | Release date: | 2022-04-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7F5T
 | | Drosophila P5CS filament with glutamate | | Descriptor: | Delta-1-pyrroline-5-carboxylate synthase, GLUTAMIC ACID | | Authors: | Liu, J.L, Zhong, J, Guo, C.J, Zhou, X. | | Deposit date: | 2021-06-22 | | Release date: | 2022-05-18 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis of dynamic P5CS filaments.
Elife, 11, 2022
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7W2B
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7W2H
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7W2C
 | | The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 | | Descriptor: | 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, GOLD ION, Sigma non-opioid intracellular receptor 1, ... | | Authors: | Meng, F, Sun, Z, Zhou, X. | | Deposit date: | 2021-11-23 | | Release date: | 2022-03-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.335 Å) | | Cite: | An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
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7W2E
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7W2G
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