8JED

Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors

Summary for 8JED

Entry DOI	10.2210/pdb8jed/pdb
Descriptor	mRNA-capping enzyme regulatory subunit OPG124 (2 entities in total)
Functional Keywords	monkeypox virus, n7-methyltransferase e12 subunit, inhibitors, transferase
Biological source	Monkeypox virus
Total number of polymer chains	1
Total formula weight	34663.89
Authors	Wang, D.,Zhao, R.,Shu, W.,Hu, W.,Wang, M.,Cao, J.,Zhou, X. (deposition date: 2023-05-15, release date: 2023-12-06)
Primary citation	Wang, D.P.,Zhao, R.,Wang, H.F.,Wang, M.Y.,Hu, W.S.,Lin, M.M.,Shu, W.,Sun, Y.J.,Cao, J.M.,Cui, W.,Zhou, X. Crystal structure of mRNA cap (guanine-N7) methyltransferase E12 subunit from monkeypox virus and discovery of its inhibitors. Int.J.Biol.Macromol., 253:127565-127565, 2023 Cited by PubMed: 37866584 DOI: 10.1016/j.ijbiomac.2023.127565 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation